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NCT07120971 · ClinicalTrials.gov registry record · Early Phase 1
Metformin for Premature Infants With Bronchopulmonary Dysplasia
A Early Phase 1 study of Bronchopulmonary Dysplasia (BPD), sponsored by Medical College of Wisconsin.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT07120971: Recruiting Early Phase 1 study of Bronchopulmonary Dysplasia (BPD), sponsored by Medical College of Wisconsin.
NCT07120971 is a Early Phase 1 study of Bronchopulmonary Dysplasia (BPD) that is actively recruiting participants, run by Medical College of Wisconsin. The registered enrollment target is 40 participants, below the 589-participant average among 5 other Bronchopulmonary Dysplasia (BPD) trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07120971, a Early Phase 1 study of Bronchopulmonary Dysplasia (BPD), is actively recruiting participants, sponsored by Medical College of Wisconsin.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall objective of this study is to investigate the role of metformin in decreasing lung injury and promoting lung growth in premature infants. There are two phases to this pilot study. For Phase 0, the goal is to investigate the safety and tolerance of oral metformin in premature who have been diagnosed with bronchopulmonary dysplasia (BPD) at 36-44 weeks gestation. For Phase 1, the goal is to investigate metformin safety and tolerance in extremely premature infants who are 7-30 days old who have an increased risk of BPD. The main questions it aims to answer are: * how well do older premature infants tolerate metformin? * how well do younger premature infants tolerate metformin?
Primary Outcome
Number of subjects who receive enteral doses of metformin and complete the study days without an adverse event while continuing enteral feedings
Conditions Studied
Interventions
- DRUG Metformin (open-label)
Study Locations (1)
Wisconsin
- Children's Wisconsin - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-12-19 |
| Est. Completion | 2030-09-01 |
| Phase | Early Phase 1 |
What NCT07120971 shows while recruiting
NCT07120971 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 589-participant average among 5 other Bronchopulmonary Dysplasia (BPD) trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Bronchopulmonary Dysplasia (BPD) appearing as the primary indexed condition, and to 1 intervention - of which Metformin (open-label) is the first listed.
NCT07120971 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT07120971 about?
NCT07120971 is a clinical study titled "Metformin for Premature Infants With Bronchopulmonary Dysplasia". The overall objective of this study is to investigate the role of metformin in decreasing lung injury and promoting lung growth in premature infants. There are two phases to this pilot study. For Phase 0, the goal is to investigate the safety and tolerance of oral metformin in premature who have bee...
What is the current status of trial NCT07120971?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 40 participants. The study started on 2025-12-19. Estimated completion is 2030-09-01.
What conditions does trial NCT07120971 study?
This clinical trial studies the following conditions: Bronchopulmonary Dysplasia (BPD).
What interventions are being tested in trial NCT07120971?
The interventions under investigation include: Metformin (open-label) (DRUG).
Who is sponsoring clinical trial NCT07120971?
This trial is sponsored by Medical College of Wisconsin, which has 447 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07120971 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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