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NCT07102381 · ClinicalTrials.gov registry record · Phase 2
A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer
A Phase 2 study of Breast Cancer and HER2-positive Breast Cancer, sponsored by Jazz Pharmaceuticals.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 125
- Enrollment target
- 20
- Study locations
NCT07102381: Recruiting Phase 2 study of Breast Cancer and HER2-positive Breast Cancer, sponsored by Jazz Pharmaceuticals.
NCT07102381 is a Phase 2 study of Breast Cancer and HER2-positive Breast Cancer that is actively recruiting participants, run by Jazz Pharmaceuticals. The registered enrollment target is 125 participants, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (96% lower). The trial reports 20 study locations across 14 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07102381, a Phase 2 study of Breast Cancer and HER2-positive Breast Cancer, is actively recruiting participants, sponsored by Jazz Pharmaceuticals.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 125 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to see if zanidatamab is safe and effective, when combined with chemotherapy, in treating people who has Human Epidermal Growth Factor Receptor 2 (HER2)-positive, early-stage breast cancer
Primary Outcome
Pathologic complete response (pCR) is defined as lacking all signs of cancer in the tissue samples removed in the breast or axilla (armpit) during surgery or biopsy after study treatment
Conditions Studied
Interventions
- DRUG Trastuzumab
- DRUG Carboplatin
- DRUG Docetaxel
- DRUG Paclitaxel
- DRUG Zanidatamab
Study Locations (20)
Texas
- Texas Oncology DFW - Dallas
- The University of Texas Southwestern Medical Center - Dallas
- Texas Oncology Gulf Coast - Houston
Virginia
- Virginia Cancer Specialists - Fairfax
- Virginia Oncology Associates - Norfolk
- Shenandoah Oncology - Winchester
Nebraska
- Cancer Partners of Nebraska - Lincoln
- Nebraska Cancer Specialists - Omaha
New Jersey
- Astera Cancer Care (Formerly Regional Cancer Care Associates) - East Brunswick
- Medical Oncology Hematology Associates - Newark
California
- Oncology Institute - Long Beach
Colorado
- Rocky Mountain Cancer Centers - Denver
Florida
- The Oncology Institute - Lakeland
Iowa
- Accellacare of McFarland - Ames
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 125 participants |
| Start Date | 2025-09-24 |
| Est. Completion | 2030-08-01 |
| Phase | Phase 2 |
What NCT07102381 shows while recruiting
NCT07102381 is an interventional study that assigns participants to a tested intervention. The registered 125 participants enrollment target is mid-sized for trials with a published cap, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (96% lower).
The record links to 2 conditions, with Breast Cancer appearing as the primary indexed condition, and to 5 interventions - of which Trastuzumab is the first listed.
NCT07102381 names 20 study sites across 14 states, led by Texas, Virginia, Nebraska.
Frequently Asked Questions
What is clinical trial NCT07102381 about?
NCT07102381 is a clinical study titled "A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer". The purpose of this study is to see if zanidatamab is safe and effective, when combined with chemotherapy, in treating people who has Human Epidermal Growth Factor Receptor 2 (HER2)-positive, early-stage breast cancer
What is the current status of trial NCT07102381?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 125 participants. The study started on 2025-09-24. Estimated completion is 2030-08-01.
What conditions does trial NCT07102381 study?
This clinical trial studies the following conditions: Breast Cancer, HER2-positive Breast Cancer.
What interventions are being tested in trial NCT07102381?
The interventions under investigation include: Trastuzumab (DRUG), Carboplatin (DRUG), Docetaxel (DRUG), Paclitaxel (DRUG), Zanidatamab (DRUG).
Who is sponsoring clinical trial NCT07102381?
This trial is sponsored by Jazz Pharmaceuticals, which has 128 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07102381 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Iowa, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Breast Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07102381's enrollment target sits among peer trials
125 499th of 1224 higher than 722 of 1,224 other Breast Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Breast Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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