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NCT07086222 · ClinicalTrials.gov registry record · Phase 4
Efficacy and Safety of NVX-CoV2705
A Phase 4 study, sponsored by Novavax.
- Active
- Registry status
- Phase 4
- Development phase
- 6,500
- Enrollment target
NCT07086222: Active Phase 4 study, sponsored by Novavax.
NCT07086222 is a Phase 4 study that is active but no longer recruiting, run by Novavax. The registered enrollment target is 6,500 participants, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (1155% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07086222, a Phase 4 study, is active but no longer recruiting, sponsored by Novavax.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 4
- Development phase
- 6,500 participants
- Enrollment target
Study Summary
This is a Phase 4, post-market US study, evaluating the efficacy and safety of a single dose of the NVX-CoV2705 Omicron JN.1 COVID-19 vaccine. Approximately 6,500 healthy adults aged 50 to under 65 will be randomized to receive either the vaccine or a placebo, with follow-up for 180 days.
Primary Outcome
First episode of PCR-positive symptomatic COVID 19 from Day 0 (post vaccination) through Day 180/EoS
Interventions
- BIOLOGICAL Placebo
- BIOLOGICAL NVX-CoV2705
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6,500 participants |
| Start Date | 2025-11-20 |
| Est. Completion | 2026-11-18 |
| Phase | Phase 4 |
What the registry record for NCT07086222 still lists
NCT07086222 is an interventional study that assigns participants to a tested intervention. Its 6,500 participants enrollment target places it among the larger protocols in the corpus, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (1155% higher).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT07086222 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07086222 about?
NCT07086222 is a clinical study titled "Efficacy and Safety of NVX-CoV2705". This is a Phase 4, post-market US study, evaluating the efficacy and safety of a single dose of the NVX-CoV2705 Omicron JN.1 COVID-19 vaccine. Approximately 6,500 healthy adults aged 50 to under 65 will be randomized to receive either the vaccine or a placebo, with follow-up for 180 days.
What is the current status of trial NCT07086222?
This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 6,500 participants. The study started on 2025-11-20. Estimated completion is 2026-11-18.
What interventions are being tested in trial NCT07086222?
The interventions under investigation include: Placebo (BIOLOGICAL), NVX-CoV2705 (BIOLOGICAL).
Who is sponsoring clinical trial NCT07086222?
This trial is sponsored by Novavax, which has 31 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07086222's enrollment target sits among peer trials
6,500 12th of 2000 higher than 1,989 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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