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A Study Evaluating the Effect of Daily Oral RO7795081 in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity
NCT07081958 · View on ClinicalTrials.gov ↗
Study Summary
This multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-range-finding, Phase II study aims to evaluate the efficacy, tolerability, and safety of RO7795081 for chronic weight management in adult participants with obesity or overweight with at least one weight-related comorbidity, but without diabetes mellitus.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG RO7795081
Study Locations (20)
North Carolina
- Accellacare of Cary — Cary
- Accellacare - Hickory — Hickory
- Accellacare of Raleigh — Raleigh
- Accellacare of Rocky Mount — Rocky Mount
- Accellacare of Salisbury — Salisbury
California
- Orange County Research Center — Lake Forest
- Prospective Research Innovations Inc. — Rancho Cucamonga
- Asclepes Research Centers — Sherman Oaks
- Encompass Clinical Research — Spring Valley
Florida
- K2 Medical Research-Winter Garden — Clermont
- K2 Medical Research - The Villages — Lady Lake
- K2 Medical Research-Maitland — Maitland
Alabama
- Pinnacle Research Group — Anniston
Connecticut
- Chase Medical Research — Waterbury
District of Columbia
- Emerson Clinical Research Institute LLC — Washington D.C.
Georgia
- Rophe Adult and Pediatric Medicine/SKYCRNG — Union City
Illinois
- Accellacare of Duly Health and Care — Oak Lawn
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 340 participants |
| Start Date | 2025-07-29 |
| Est. Completion | 2026-07-17 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07081958
The ClinicalTrials.gov registry entry for NCT07081958 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 340 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Obesity or Overweight appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07081958 reports 20 study locations spanning 11 distinct geographic areas — top geographies include North Carolina, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07081958 about?
NCT07081958 is a clinical study titled "A Study Evaluating the Effect of Daily Oral RO7795081 in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity". This multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-range-finding, Phase II study aims to evaluate the efficacy, tolerability, and safety of RO7795081 for chronic weight management in adult participants with obesity or overweight with at least one weight-related como...
What is the current status of trial NCT07081958?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 340 participants. The study started on 2025-07-29. Estimated completion is 2026-07-17.
What conditions does trial NCT07081958 study?
This clinical trial studies the following conditions: Obesity or Overweight. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07081958?
The interventions under investigation include: Placebo (DRUG), RO7795081 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07081958?
This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07081958 being conducted?
This trial has 20 study locations across Alabama, California, Connecticut, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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