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NCT07076485 · ClinicalTrials.gov registry record · Phase 2
Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer
A Phase 2 study of Breast Cancer, sponsored by M.D. Anderson Cancer Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 768
- Enrollment target
- 2
- Study locations
NCT07076485: Recruiting Phase 2 study of Breast Cancer, sponsored by M.D. Anderson Cancer Center.
NCT07076485 is a Phase 2 study of Breast Cancer that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 768 participants, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (73% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07076485, a Phase 2 study of Breast Cancer, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 768 participants
- Enrollment target
- 2
- Study locations
Study Summary
To learn about the effects of shorter RNI regimens in patients with breast cance who have had a lumpectomy or mastectomy and who are at higher risk for lower risk for the disease returning.
Primary Outcome
Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0
Conditions Studied
Interventions
- RADIATION Ultrahypofractionated Radiation
- RADIATION Moderately Hypofractionated Radiation
Study Locations (2)
New Jersey
- Cooper Hospital University Medical Center - Voorhees Township
Texas
- The University of Texas M. D. Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 768 participants |
| Start Date | 2025-08-19 |
| Est. Completion | 2031-01-01 |
| Phase | Phase 2 |
What NCT07076485 shows while recruiting
NCT07076485 is an interventional study that assigns participants to a tested intervention. The registered 768 participants enrollment target is mid-sized for trials with a published cap, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (73% lower).
The record links to 1 condition, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions - of which Ultrahypofractionated Radiation is the first listed.
NCT07076485 reports a single indexed study location in New Jersey, Texas.
Frequently Asked Questions
What is clinical trial NCT07076485 about?
NCT07076485 is a clinical study titled "Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer". To learn about the effects of shorter RNI regimens in patients with breast cance who have had a lumpectomy or mastectomy and who are at higher risk for lower risk for the disease returning.
What is the current status of trial NCT07076485?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 768 participants. The study started on 2025-08-19. Estimated completion is 2031-01-01.
What conditions does trial NCT07076485 study?
This clinical trial studies the following conditions: Breast Cancer.
What interventions are being tested in trial NCT07076485?
The interventions under investigation include: Ultrahypofractionated Radiation (RADIATION), Moderately Hypofractionated Radiation (RADIATION).
Who is sponsoring clinical trial NCT07076485?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07076485 being conducted?
This trial has 2 study locations across New Jersey, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Breast Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07076485's enrollment target sits among peer trials
768 147th of 1224 higher than 1,078 of 1,224 other Breast Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Breast Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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