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NCT07063446 · ClinicalTrials.gov registry record · NA
sTMS Combined With CIMT and taVNS In Infants With Hemiplegia
A NA study of Hemiplegia and Perinatal Brain Injury, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT07063446: Recruiting NA study of Hemiplegia and Perinatal Brain Injury, sponsored by Medical University of South Carolina.
NCT07063446 is a NA study of Hemiplegia and Perinatal Brain Injury that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 10 participants, below the 69-participant average among 13 other Hemiplegia trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07063446, a NA study of Hemiplegia and Perinatal Brain Injury, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
Preterm and term infants with brain injury frequently have delayed motor skills, and one hand and arm may become stronger than the other, which can signal early cerebral palsy. A new treatment, transcutaneous vagus nerve stimulation (taVNS), boosts specific brain circuits and may improve function when paired with intensive motor activities. This study will test taVNS-paired constraint induced movement therapy in infants who have greater weakness on one side and determine if a single pulse of transcranial brain stimulation over the motor area can cause a measurable movement of the hand or thumb, and indicate which infants can benefit from 40h taVNS-paired CIMT.
Primary Outcome
Percent Change in the mini-AHA or AHA from baseline to end of treatment- the standardized scale on the Assisted hand assessments range from 0-100 where 100 indicates greatest possible functional use of the hand and 0 indicates no hand function
Conditions Studied
Interventions
- DEVICE taVNS
- DEVICE sTMS
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2025-11-07 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What NCT07063446 shows while recruiting
NCT07063446 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 69-participant average among 13 other Hemiplegia trials with a reported enrollment target (86% lower).
The record links to 2 conditions, with Hemiplegia appearing as the primary indexed condition, and to 2 interventions - of which taVNS is the first listed.
NCT07063446 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT07063446 about?
NCT07063446 is a clinical study titled "sTMS Combined With CIMT and taVNS In Infants With Hemiplegia". Preterm and term infants with brain injury frequently have delayed motor skills, and one hand and arm may become stronger than the other, which can signal early cerebral palsy. A new treatment, transcutaneous vagus nerve stimulation (taVNS), boosts specific brain circuits and may improve function wh...
What is the current status of trial NCT07063446?
This trial is currently recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2025-11-07. Estimated completion is 2026-12-31.
What conditions does trial NCT07063446 study?
This clinical trial studies the following conditions: Hemiplegia, Perinatal Brain Injury.
What interventions are being tested in trial NCT07063446?
The interventions under investigation include: taVNS (DEVICE), sTMS (DEVICE).
Who is sponsoring clinical trial NCT07063446?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07063446 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hemiplegia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07063446's enrollment target sits among peer trials
10 10th of 13 higher than 3 of 13 other Hemiplegia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hemiplegia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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