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NCT07050433 · ClinicalTrials.gov registry record
COMPASS Study for Metastatic Castration-resistant Prostate Cancer
A clinical trial of Prostate Cancer, sponsored by Duke University.
- Recruiting
- Registry status
- 48
- Enrollment target
- 1
- Study location
NCT07050433: Recruiting study of Prostate Cancer, sponsored by Duke University.
NCT07050433 is a study of Prostate Cancer that is actively recruiting participants, run by Duke University. The registered enrollment target is 48 participants, below the 608-participant average among 735 other Prostate Cancer trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07050433, a study of Prostate Cancer, is actively recruiting participants, sponsored by Duke University.
- RECRUITING
- Registry status
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
This study is a companion to the SYNERGY-201 clinical trial (NCT06228053), which investigates SX-682 and enzalutamide in individuals with prostate cancer. Individuals must be participating in SYNERGY-201 in order to participate in this study. The purpose of this companion study is to learn more about biomarkers, particularly a biomarker called CXCR2, and investigate if CXCR2 can predict who will receive benefit from the SYNERGY-201 drug combination. This study will also investigate how CXCR2 and other biomarkers change over time when participants receive the SYNERGY-201 drug combination. CXCR2 is of particular interest because the SYNERGY-201 drug, SX-682, inhibits CXCR2. After participants provide consent, blood samples will be collected for research purposes at three SYNERGY-201 visits (Baseline, Cycle 3 Day 1 and End of Study Drug). Up to 20 participants will also receive tumor biopsies at the Baseline and SYNERGY-201 Cycle 3 Day 1 visits. Clinical and study data collected as part of SYNERGY-201 will also be used for this study.
Primary Outcome
The association between tumor CXCR2 (dichotomized as absent or present CXCR2 levels in tumor at baseline as compared to negative control tissue) and CB will be measured using an odds ratio with 95% CI.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST CXCR2 as a biomarker
Study Locations (1)
North Carolina
- Duke University - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2025-08-07 |
| Est. Completion | 2028-01-01 |
What NCT07050433 shows while recruiting
NCT07050433 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 608-participant average among 735 other Prostate Cancer trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Prostate Cancer appearing as the primary indexed condition, and to 1 intervention - of which CXCR2 as a biomarker is the first listed.
NCT07050433 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT07050433 about?
NCT07050433 is a clinical study titled "COMPASS Study for Metastatic Castration-resistant Prostate Cancer". This study is a companion to the SYNERGY-201 clinical trial (NCT06228053), which investigates SX-682 and enzalutamide in individuals with prostate cancer. Individuals must be participating in SYNERGY-201 in order to participate in this study. The purpose of this companion study is to learn more abou...
What is the current status of trial NCT07050433?
This trial is currently recruiting. The enrollment target is 48 participants. The study started on 2025-08-07. Estimated completion is 2028-01-01.
What conditions does trial NCT07050433 study?
This clinical trial studies the following conditions: Prostate Cancer.
What interventions are being tested in trial NCT07050433?
The interventions under investigation include: CXCR2 as a biomarker (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07050433?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07050433 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Prostate Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07050433's enrollment target sits among peer trials
48 496th of 735 higher than 235 of 735 other Prostate Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Prostate Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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