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NCT07037940 · ClinicalTrials.gov registry record · NA
Physician Response Evaluation With Contextual Insights vs. Standard Engines - Artificial Intelligence RAG vs LLM Clinical Decision Support
A NA study of Large Language Models, sponsored by Montefiore Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 26
- Enrollment target
- 2
- Study locations
NCT07037940: Recruiting NA study of Large Language Models, sponsored by Montefiore Medical Center.
NCT07037940 is a NA study of Large Language Models that is actively recruiting participants, run by Montefiore Medical Center. The registered enrollment target is 26 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07037940, a NA study of Large Language Models, is actively recruiting participants, sponsored by Montefiore Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 26 participants
- Enrollment target
- 2
- Study locations
Study Summary
Clinical decision support tools powered by artificial intelligence are being rapidly integrated into medical practice. Two leading systems currently available to clinicians are OpenEvidence, which uses retrieval-augmented generation to access medical literature, and GPT-4, a large language model. While both tools show promise, their relative effectiveness in supporting clinical decision-making has not been directly compared. This study aims to evaluate how these tools influence diagnostic reasoning and management decisions among internal medicine physicians.
Primary Outcome
Clinical reasoning performance will be evaluated based upon the accuracy of the rater scores to responses to the surveys administered. Six blinded, trained independent raters will independently score each participant's response using a validated scoring rubric. Possible response scores can range from 0-100% with higher scores indicating increased clinical reasoning performance. Results for each assessment will be summarized by study arm using basic descriptive statistics and analyzed using mixed
Conditions Studied
Interventions
- OTHER OpenEvidence
- OTHER GPT-4
Study Locations (2)
Massachusetts
- Harvard Beth Israel Deaconess Medical Center - Boston
New York
- MontefioreMC - The Bronx
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2025-07-03 |
| Est. Completion | 2026-02 |
| Phase | NA |
What NCT07037940 shows while recruiting
NCT07037940 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Large Language Models appearing as the primary indexed condition, and to 2 interventions - of which OpenEvidence is the first listed.
NCT07037940 reports a single indexed study location in Massachusetts, New York.
Frequently Asked Questions
What is clinical trial NCT07037940 about?
NCT07037940 is a clinical study titled "Physician Response Evaluation With Contextual Insights vs. Standard Engines - Artificial Intelligence RAG vs LLM Clinical Decision Support". Clinical decision support tools powered by artificial intelligence are being rapidly integrated into medical practice. Two leading systems currently available to clinicians are OpenEvidence, which uses retrieval-augmented generation to access medical literature, and GPT-4, a large language model. Wh...
What is the current status of trial NCT07037940?
This trial is currently recruiting. It is a NA study. The enrollment target is 26 participants. The study started on 2025-07-03. Estimated completion is 2026-02.
What conditions does trial NCT07037940 study?
This clinical trial studies the following conditions: Large Language Models.
What interventions are being tested in trial NCT07037940?
The interventions under investigation include: OpenEvidence (OTHER), GPT-4 (OTHER).
Who is sponsoring clinical trial NCT07037940?
This trial is sponsored by Montefiore Medical Center, which has 345 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07037940 being conducted?
This trial has 2 study locations across Massachusetts, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07037940's enrollment target sits among peer trials
26 1710th of 2000 higher than 289 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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