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NCT07011758 · ClinicalTrials.gov registry record · Phase 2
Dynamic Treatment Regimes for Opioid Use Disorder
A Phase 2 study, sponsored by Brigham and Women's Hospital.
- Not yet
- Registry status
- Phase 2
- Development phase
- 75
- Enrollment target
NCT07011758: Clinical Trial Phase 2 study, sponsored by Brigham and Women's Hospital.
NCT07011758 is a Phase 2 study that has not yet begun recruiting, run by Brigham and Women's Hospital. The registered enrollment target is 75 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (44% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07011758, a Phase 2 study, has not yet begun recruiting, sponsored by Brigham and Women's Hospital.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 75 participants
- Enrollment target
Study Summary
This study aims to develop and evaluate dynamic treatment regimes (DTRs) to improve personalized care for individuals with opioid use disorder (OUD). Using machine learning methods and longitudinal data from a national behavioral health provider, the investigators will identify optimal treatment sequences that minimize the risk of overdose and improve recovery outcomes. A pilot hybrid factorial SMART trial will be conducted to assess the feasibility and acceptability of implementing these personalized treatment decision rules in real-world clinical settings.
Primary Outcome
Weekly Computerized Adaptive Test for Substance Use Disorder severity T-score. Scores range 0-100 (≈5-point precision). Higher scores indicate a greater SUD symptom burden/risk, while lower scores indicate fewer symptoms/lower risk. Prior validation studies have used \<50 = low, 50-70 = intermediate, \>70 = high severity/risk thresholds. Computerized Adaptive Test for Substance Use Disorder provides a dimensional severity score (not a diagnosis). Change is assessed week-to-week.
Interventions
- BEHAVIORAL psychotherapy
- DRUG Medication for opioid use disorder
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2028-07-01 |
| Est. Completion | 2030-06-01 |
| Phase | Phase 2 |
What is known before NCT07011758 opens enrollment
NCT07011758 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (44% lower).
The record links to 0 conditions, and to 2 interventions - of which psychotherapy is the first listed.
NCT07011758 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07011758 about?
NCT07011758 is a clinical study titled "Dynamic Treatment Regimes for Opioid Use Disorder". This study aims to develop and evaluate dynamic treatment regimes (DTRs) to improve personalized care for individuals with opioid use disorder (OUD). Using machine learning methods and longitudinal data from a national behavioral health provider, the investigators will identify optimal treatment seq...
What is the current status of trial NCT07011758?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 75 participants. The study started on 2028-07-01. Estimated completion is 2030-06-01.
What interventions are being tested in trial NCT07011758?
The interventions under investigation include: psychotherapy (BEHAVIORAL), Medication for opioid use disorder (DRUG).
Who is sponsoring clinical trial NCT07011758?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07011758's enrollment target sits among peer trials
75 900th of 2000 higher than 1,081 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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