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NCT06993142 · ClinicalTrials.gov registry record · NA
Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage
A NA study, sponsored by Radboud University Medical Center.
- Not yet
- Registry status
- NA
- Development phase
- 600
- Enrollment target
NCT06993142 is a NA study that has not yet begun recruiting, run by Radboud University Medical Center. The registered enrollment target is 600 participants.
The verdict
NCT06993142, a NA study, has not yet begun recruiting, sponsored by Radboud University Medical Center.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 600 participants
- Enrollment target
Study Summary
The goal of this clinical trial is two-fold. First to investigate the feasibility of whether a remotely administered smartphone app can increase the volume and intensity of physical activity in daily life in individuals with a LRRK2 G2019S or GBA1 N370S genetic mutation over a long period of time (24 months). Second, to explore the preliminary efficacy of exercise on markers for prodromal Parkinson's disease progression in individuals with a LRRK2 G2019S or GBA1 N370S genetic mutation. Participants will be tasked to achieve an incremental increase of daily steps (volume) and amount of minutes exercised at a certain heart rate (intensity) with respect to their own baseline level. Motivation with regards to physical activity will entirely be communicated through the study specific Slow Speed smartphone app. A joint primary objective consists of two components. First to determine the longitudinal effect of an exercise intervention in LRRK2 G2019S or GBA1 N370S variant carriers on a prodromal load score, comprised of digital biomarkers of prodromal symptoms. The secondary component of the primary outcome is to determine the feasibility of a remote intervention study. The secondary objective is the effect of a physical activity intervention on digital markers of physical fitness. Exploratory outcomes entail retention rate, completeness of remote digital biomarker assessments, digital prodromal motor and non-motor features of PD. Using these biomarkers, the investigators aim to develop a composite score (prodromal load score) to estimate the total prodromal load. An international exercise study with fellow researchers in the United Kingdom are currently in preparation (Slow-SPEED-UK) and active in the Netherlands (Slow-SPEED-NL). Our intention is to analyse overlapping outcomes combined where possible through a meta-analysis plan, to obtain insight on (determinants of) heterogeneity in compliance and possible efficacy across subgroups
Interventions
- BEHAVIORAL Increase of physical activity volume and intensity with the use of a motivational smartphone application
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2025-07-01 |
| Est. Completion | 2029-06-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06993142
The ClinicalTrials.gov registry entry for NCT06993142 describes a study currently listed as not yet recruiting, categorized as NA. The registered enrollment target is 600 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Radboud University Medical Center, which has 6 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Increase of physical activity volume and intensity with the use of a motivational smartphone application is the first listed.
NCT06993142 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT06993142 about?
NCT06993142 is a clinical study titled "Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage". The goal of this clinical trial is two-fold. First to investigate the feasibility of whether a remotely administered smartphone app can increase the volume and intensity of physical activity in daily life in individuals with a LRRK2 G2019S or GBA1 N370S genetic mutation over a long period of time (2...
What is the current status of trial NCT06993142?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 600 participants. The study started on 2025-07-01. Estimated completion is 2029-06-30.
What interventions are being tested in trial NCT06993142?
The interventions under investigation include: Increase of physical activity volume and intensity with the use of a motivational smartphone application (BEHAVIORAL).
Who is sponsoring clinical trial NCT06993142?
This trial is sponsored by Radboud University Medical Center, which has 6 total clinical trials registered on ClinicalTrials.gov.
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