Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06993142 · ClinicalTrials.gov registry record · NA
Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage
A NA study, sponsored by Radboud University Medical Center.
- Not yet
- Registry status
- NA
- Development phase
- 600
- Enrollment target
NCT06993142: Clinical Trial NA study, sponsored by Radboud University Medical Center.
NCT06993142 is a NA study that has not yet begun recruiting, run by Radboud University Medical Center. The registered enrollment target is 600 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (57% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06993142, a NA study, has not yet begun recruiting, sponsored by Radboud University Medical Center.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 600 participants
- Enrollment target
Study Summary
The goal of this clinical trial is two-fold. First to investigate the feasibility of whether a remotely administered smartphone app can increase the volume and intensity of physical activity in daily life in individuals with a LRRK2 G2019S or GBA1 N370S genetic mutation over a long period of time (24 months). Second, to explore the preliminary efficacy of exercise on markers for prodromal Parkinson's disease progression in individuals with a LRRK2 G2019S or GBA1 N370S genetic mutation. Participants will be tasked to achieve an incremental increase of daily steps (volume) and amount of minutes exercised at a certain heart rate (intensity) with respect to their own baseline level. Motivation with regards to physical activity will entirely be communicated through the study specific Slow Speed smartphone app. A joint primary objective consists of two components. First to determine the longitudinal effect of an exercise intervention in LRRK2 G2019S or GBA1 N370S variant carriers on a prodromal load score, comprised of digital biomarkers of prodromal symptoms. The secondary component of the primary outcome is to determine the feasibility of a remote intervention study. The secondary objective is the effect of a physical activity intervention on digital markers of physical fitness. Exploratory outcomes entail retention rate, completeness of remote digital biomarker assessments, digital prodromal motor and non-motor features of PD. Using these biomarkers, the investigators aim to develop a composite score (prodromal load score) to estimate the total prodromal load. An international exercise study with fellow researchers in the United Kingdom are currently in preparation (Slow-SPEED-UK) and active in the Netherlands (Slow-SPEED-NL). Our intention is to analyse overlapping outcomes combined where possible through a meta-analysis plan, to obtain insight on (determinants of) heterogeneity in compliance and possible efficacy across subgroups
Primary Outcome
Change in prodromal load score, comprised of digital biomarkers for prodromal symptoms. The score is currently under development.
Interventions
- BEHAVIORAL Increase of physical activity volume and intensity with the use of a motivational smartphone application
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2025-07-01 |
| Est. Completion | 2029-06-30 |
| Phase | NA |
What is known before NCT06993142 opens enrollment
NCT06993142 is an interventional study that assigns participants to a tested intervention. The registered 600 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (57% lower).
The record links to 0 conditions, and to 1 intervention - of which Increase of physical activity volume and intensity with the use of a motivational smartphone application is the first listed.
NCT06993142 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06993142 about?
NCT06993142 is a clinical study titled "Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage". The goal of this clinical trial is two-fold. First to investigate the feasibility of whether a remotely administered smartphone app can increase the volume and intensity of physical activity in daily life in individuals with a LRRK2 G2019S or GBA1 N370S genetic mutation over a long period of time (2...
What is the current status of trial NCT06993142?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 600 participants. The study started on 2025-07-01. Estimated completion is 2029-06-30.
What interventions are being tested in trial NCT06993142?
The interventions under investigation include: Increase of physical activity volume and intensity with the use of a motivational smartphone application (BEHAVIORAL).
Who is sponsoring clinical trial NCT06993142?
This trial is sponsored by Radboud University Medical Center, which has 6 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06993142's enrollment target sits among peer trials
600 162nd of 2000 higher than 1,827 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00004317 · 600 participants · Phase 4
Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis
- NCT00209235 · 600 participants · NA
Albright Hereditary Osteodystrophy: Natural History, Growth, and Cognitive/Behavioral Assessments
- NCT01473784 · 600 participants · NA
Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck
- NCT01866371 · 600 participants
High Resolution Retinal Imaging
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI