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NCT06980090 · ClinicalTrials.gov registry record · NA
Neural Mechanisms of Interpersonal Expectations on Negative Affect
A NA study of Placebo Effect and Negative Affectivity, sponsored by Trustees of Dartmouth College.
- Recruiting
- Registry status
- NA
- Development phase
- 190
- Enrollment target
- 1
- Study location
NCT06980090: Recruiting NA study of Placebo Effect and Negative Affectivity, sponsored by Trustees of Dartmouth College.
NCT06980090 is a NA study of Placebo Effect and Negative Affectivity that is actively recruiting participants, run by Trustees of Dartmouth College. The registered enrollment target is 190 participants, below the 425-participant average among 3 other Placebo Effect trials with a reported enrollment target (55% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06980090, a NA study of Placebo Effect and Negative Affectivity, is actively recruiting participants, sponsored by Trustees of Dartmouth College.
- RECRUITING
- Registry status
- NA
- Development phase
- 190 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects. The main questions this study aims to answer are: (1)Does active tTIS reduce negative affect more effectively than sham (inactive) tTIS? (2)Do positive treatment expectations enhance the effects compared to negative expectations? Participants will: (1) Receive either active or sham tTIS. (2) Be provided with positive or negative messaging regarding treatment effectiveness. (3) Interact with care providers and complete assessments measuring negative affect and physiological responses.
Primary Outcome
Participants report cognitive effort after each trial on a Generalized Linear Magnitude scale (GLMS) with anchors of "No effort" and "Most effort imaginable". Raw units are on a 0-180 scale.
Conditions Studied
Interventions
- BEHAVIORAL Session A: Positive Placebo + Active tTIS
- BEHAVIORAL Session B: Positive Placebo + Sham tTIS
- BEHAVIORAL Session C: Negative Placebo + Active tTIS
- BEHAVIORAL Session D: Negative Placebo + Sham tTIS
- BEHAVIORAL Session E: On-Placebo + Sham tTIS
Study Locations (1)
New Hampshire
- Dartmouth College, Department of Psychological and Brain Sciences - Hanover
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 190 participants |
| Start Date | 2025-09-01 |
| Est. Completion | 2027-03-03 |
| Phase | NA |
What NCT06980090 shows while recruiting
NCT06980090 is an interventional study that assigns participants to a tested intervention. The registered 190 participants enrollment target is mid-sized for trials with a published cap, below the 425-participant average among 3 other Placebo Effect trials with a reported enrollment target (55% lower).
The record links to 4 conditions, with Placebo Effect appearing as the primary indexed condition, and to 5 interventions - of which Session A: Positive Placebo + Active tTIS is the first listed.
NCT06980090 reports a single indexed study location in New Hampshire.
Frequently Asked Questions
What is clinical trial NCT06980090 about?
NCT06980090 is a clinical study titled "Neural Mechanisms of Interpersonal Expectations on Negative Affect". The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects. The main questions this study aims to answer are: (1)D...
What is the current status of trial NCT06980090?
This trial is currently recruiting. It is a NA study. The enrollment target is 190 participants. The study started on 2025-09-01. Estimated completion is 2027-03-03.
What conditions does trial NCT06980090 study?
This clinical trial studies the following conditions: Placebo Effect, Negative Affectivity, Expectations, Non-invasive Brain Stimulation.
What interventions are being tested in trial NCT06980090?
The interventions under investigation include: Session A: Positive Placebo + Active tTIS (BEHAVIORAL), Session B: Positive Placebo + Sham tTIS (BEHAVIORAL), Session C: Negative Placebo + Active tTIS (BEHAVIORAL), Session D: Negative Placebo + Sham tTIS (BEHAVIORAL), Session E: On-Placebo + Sham tTIS (BEHAVIORAL).
Who is sponsoring clinical trial NCT06980090?
This trial is sponsored by Trustees of Dartmouth College, which has 31 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06980090 being conducted?
This trial has 1 study location across New Hampshire. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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