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Neural Mechanisms of Interpersonal Expectations on Negative Affect
NCT06980090 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects. The main questions this study aims to answer are: (1)Does active tTIS reduce negative affect more effectively than sham (inactive) tTIS? (2)Do positive treatment expectations enhance the effects compared to negative expectations? Participants will: (1) Receive either active or sham tTIS. (2) Be provided with positive or negative messaging regarding treatment effectiveness. (3) Interact with care providers and complete assessments measuring negative affect and physiological responses.
Conditions Studied
Interventions
- BEHAVIORAL Session A: Positive Placebo + Active tTIS
- BEHAVIORAL Session B: Positive Placebo + Sham tTIS
- BEHAVIORAL Session C: Negative Placebo + Active tTIS
- BEHAVIORAL Session D: Negative Placebo + Sham tTIS
- BEHAVIORAL Session E: On-Placebo + Sham tTIS
Study Locations (1)
New Hampshire
- Dartmouth College, Department of Psychological and Brain Sciences — Hanover
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 190 participants |
| Start Date | 2025-09-01 |
| Est. Completion | 2027-03-03 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06980090
The ClinicalTrials.gov registry entry for NCT06980090 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 190 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Trustees of Dartmouth College, which has 14 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Placebo Effect appearing as the primary indexed condition, and to 5 interventions — of which Session A: Positive Placebo + Active tTIS is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06980090 reports 1 study location spanning 1 distinct geographic area — top geographies include New Hampshire. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06980090 about?
NCT06980090 is a clinical study titled "Neural Mechanisms of Interpersonal Expectations on Negative Affect". The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects. The main questions this study aims to answer are: (1)D...
What is the current status of trial NCT06980090?
This trial is currently recruiting. It is a NA study. The enrollment target is 190 participants. The study started on 2025-09-01. Estimated completion is 2027-03-03.
What conditions does trial NCT06980090 study?
This clinical trial studies the following conditions: Placebo Effect, Negative Affectivity, Expectations, Non-invasive Brain Stimulation. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06980090?
The interventions under investigation include: Session A: Positive Placebo + Active tTIS (BEHAVIORAL), Session B: Positive Placebo + Sham tTIS (BEHAVIORAL), Session C: Negative Placebo + Active tTIS (BEHAVIORAL), Session D: Negative Placebo + Sham tTIS (BEHAVIORAL), Session E: On-Placebo + Sham tTIS (BEHAVIORAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06980090?
This trial is sponsored by Trustees of Dartmouth College, which has 14 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06980090 being conducted?
This trial has 1 study location across New Hampshire. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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