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NCT06969846 · ClinicalTrials.gov registry record · NA
Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects
A NA study, sponsored by Louis Stokes VA Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 18
- Enrollment target
NCT06969846: Completed NA study, sponsored by Louis Stokes VA Medical Center.
NCT06969846 is a NA study that has completed, run by Louis Stokes VA Medical Center. The registered enrollment target is 18 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06969846, a NA study, has completed, sponsored by Louis Stokes VA Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 18 participants
- Enrollment target
Study Summary
Uncontrolled hypertension (HTN) is growing in incidence globally creating a critical need for alternative therapeutic strategies. Directly stimulating the carotid sinus nerve (CSN) is known to potentially reduce blood pressure (BP) but its clinical efficacy has not been consistently demonstrated with existing electrode technologies in humans. We investigated the effect of acute direct CSN stimulation on BP and HR in anesthetized humans using an application-specific multi-contact electrode.
Primary Outcome
The primary outcome was maximum drops and recovery in systolic blood pressure (SBP) as a function of carotid sinus nerve (CSN) stimulation as measured in mmHg. The maximum drop was calculated as the maximum change in SBP while stimulus was active, relative to the baseline value 30 seconds before starting stimulus. Maximum recovery was calculated as the largest change in SBP within 30 seconds of ending stimulus relative to the nadir in SBP (mmHg) during stimulation.
Interventions
- DEVICE CSN electrode was implanted around tissue including CSN branches
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2020-04-03 |
| Est. Completion | 2024-08-12 |
| Phase | NA |
What the finished NCT06969846 record still lists
NCT06969846 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which CSN electrode was implanted around tissue including CSN branches is the first listed.
NCT06969846 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06969846 about?
NCT06969846 is a clinical study titled "Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects". Uncontrolled hypertension (HTN) is growing in incidence globally creating a critical need for alternative therapeutic strategies. Directly stimulating the carotid sinus nerve (CSN) is known to potentially reduce blood pressure (BP) but its clinical efficacy has not been consistently demonstrated wit...
What is the current status of trial NCT06969846?
This trial is currently completed. It is a NA study. The enrollment target is 18 participants. The study started on 2020-04-03. Estimated completion is 2024-08-12.
What interventions are being tested in trial NCT06969846?
The interventions under investigation include: CSN electrode was implanted around tissue including CSN branches (DEVICE).
Who is sponsoring clinical trial NCT06969846?
This trial is sponsored by Louis Stokes VA Medical Center, which has 10 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06969846's enrollment target sits among peer trials
18 1863rd of 2000 higher than 130 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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