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NCT06951516 · ClinicalTrials.gov registry record · NA
How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome
A NA study of Down Syndrome, sponsored by Michigan State University.
- Recruiting
- Registry status
- NA
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT06951516: Recruiting NA study of Down Syndrome, sponsored by Michigan State University.
NCT06951516 is a NA study of Down Syndrome that is actively recruiting participants, run by Michigan State University. The registered enrollment target is 30 participants, below the 2,471-participant average among 54 other Down Syndrome trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06951516, a NA study of Down Syndrome, is actively recruiting participants, sponsored by Michigan State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with Down syndrome (DS). The overall objective is to determine how single-word and telegraphic simplification affects real-time language processing and word learning in young children with DS (relative to full, grammatical utterances). The proposed project will investigate three specific aims: 1) Determine how single-word and telegraphic simplification affects language processing. 2) Determine how single-word and telegraphic simplification affects word learning. 3) Evaluate child characteristics that may moderate the effects of linguistic simplification on language processing and word learning. Aim 1 will test the hypothesis that children with DS will process grammatical utterances faster and more accurately than telegraphic or single-word utterances. Aim 2 will test the hypothesis that overall, children will demonstrate better word learning in the grammatical compared to the single-word and telegraphic conditions. Aim 3 will test the hypothesis that receptive language and nonverbal cognitive abilities will be significant moderators, such that children with stronger linguistic and cognitive skills will show the greatest benefit from grammatical input but children with lower linguistic and cognitive scores will perform similarly across conditions.
Primary Outcome
LWL involves a child looking at a screen with two images, one on each side of the screen, while being provided an auditory cue that includes the name of the target image. The primary outcome is a dichotomous variable indicating whether the child is fixated on the target image or the distracter image; gaze directed at neither image will be considered missing. It will be determined whether gaze is to the left or right image, using trained coders who are blind to target side. Gaze location will be
Conditions Studied
Interventions
- BEHAVIORAL Linguistic simplification
Study Locations (1)
Michigan
- Michigan State University - East Lansing
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2025-01-01 |
| Est. Completion | 2027-05-31 |
| Phase | NA |
What NCT06951516 shows while recruiting
NCT06951516 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 2,471-participant average among 54 other Down Syndrome trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Down Syndrome appearing as the primary indexed condition, and to 1 intervention - of which Linguistic simplification is the first listed.
NCT06951516 reports a single indexed study location in Michigan.
Frequently Asked Questions
What is clinical trial NCT06951516 about?
NCT06951516 is a clinical study titled "How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome". The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with Down syndrome (DS). The overall objective is to determine how single-word and telegraphic simplification affects real-time language processing...
What is the current status of trial NCT06951516?
This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2025-01-01. Estimated completion is 2027-05-31.
What conditions does trial NCT06951516 study?
This clinical trial studies the following conditions: Down Syndrome.
What interventions are being tested in trial NCT06951516?
The interventions under investigation include: Linguistic simplification (BEHAVIORAL).
Who is sponsoring clinical trial NCT06951516?
This trial is sponsored by Michigan State University, which has 120 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06951516 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Down Syndrome
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06951516's enrollment target sits among peer trials
30 41st of 54 higher than 14 of 54 other Down Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Down Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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