Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06950099 · ClinicalTrials.gov registry record
Advanced Neuroimaging in Idiopathic Intracranial Hypertension
A clinical trial of Idiopathic Intracranial Hypertension (IIH) and Glymphatic System, sponsored by Thomas Jefferson University.
- Recruiting
- Registry status
- 30
- Enrollment target
- 1
- Study location
NCT06950099 is a study of Idiopathic Intracranial Hypertension (IIH) and Glymphatic System that is actively recruiting participants, run by Thomas Jefferson University. The registered enrollment target is 30 participants. The trial reports 1 study location across 1 state.
The verdict
NCT06950099, a study of Idiopathic Intracranial Hypertension (IIH) and Glymphatic System, is actively recruiting participants, sponsored by Thomas Jefferson University.
- RECRUITING
- Registry status
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure leading to symptoms like papilledema, headache, and cognitive dysfunction. While the etiology is complex, abnormal cerebrospinal fluid dynamics due to venous outflow restriction from transverse sinus stenosis (TSS) is common. TSS may disrupt the glymphatic system, a brain-wide network facilitating cerebrospinal fluid and interstitial fluid exchange, by impairing CSF absorption, altering perivascular space dynamics, and disrupting pressure gradients crucial for waste clearance. Venous sinus stenting (VSS) can improve symptoms in many patients by alleviating venous congestion, but its effects on glymphatic function are unclear. This prospective study aims to evaluate novel quantitative brain imaging metrics as surrogate markers to better understand IIH pathophysiology before and after VSS in patients with refractory IIH and TSS. The investigators will use advanced MRI techniques, including MR elastography (MRE) to assess brain stiffness, diffusion tensor imaging (DTI) to evaluate water diffusion, arterial spin labeling (ASL) imaging to measure blood-brain barrier (BBB) permeability, and functional MRI to analyze pain networks. The investigators hypothesize that 1) these noninvasive imaging metrics will correlate with the degree of venous congestion and changes after venous sinus stenting (VSS) and 2) the imaging findings will correlate with clinical treatment outcomes. By correlating imaging markers with venous pressures and symptom changes, the investigators aim to gain insights into IIH mechanisms, expand diagnostic tools, and potentially guide clinical decision-making and treatment response monitoring. The overarching goal is to better understand IIH's underlying pathophysiology, which could lead to improved diagnostic criteria, more targeted treatments, and better prediction of treatment outcomes for patients with this challenging condition.
Conditions Studied
Study Locations (1)
Pennsylvania
- Jefferson Headache Center - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2025-03-03 |
| Est. Completion | 2025-12-31 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06950099
The ClinicalTrials.gov registry entry for NCT06950099 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Thomas Jefferson University, which has 292 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Idiopathic Intracranial Hypertension (IIH) appearing as the primary indexed condition, and to 0 interventions.
NCT06950099 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06950099 about?
NCT06950099 is a clinical study titled "Advanced Neuroimaging in Idiopathic Intracranial Hypertension". Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure leading to symptoms like papilledema, headache, and cognitive dysfunction. While the etiology is complex, abnormal cerebrospinal fluid dynamics due to venous outflow restriction from transverse sinus stenos...
What is the current status of trial NCT06950099?
This trial is currently recruiting. The enrollment target is 30 participants. The study started on 2025-03-03. Estimated completion is 2025-12-31.
What conditions does trial NCT06950099 study?
This clinical trial studies the following conditions: Idiopathic Intracranial Hypertension (IIH), Glymphatic System.
Who is sponsoring clinical trial NCT06950099?
This trial is sponsored by Thomas Jefferson University, which has 292 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06950099 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Idiopathic Intracranial Hypertension (IIH)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Explore more on PlainTrial
Idiopathic Intracranial Hypertension (IIH)
All registered trials for this condition
Glymphatic System
All registered trials for this condition
Pennsylvania
All trials with a study site in Pennsylvania
Recruiting now
Find trials open to new participants near you
Rankings
Top sponsors, conditions, and phases
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.