Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT06939348 · ClinicalTrials.gov registry record · NA

Ultrasound Stimulation for Patients in a Disorder of Consciousness

A NA study of Consciousness Disorders and Disorders of Consciousness Due to Severe Brain Injury, sponsored by University of California, Los Angeles.

Recruiting
Registry status
NA
Development phase
60
Enrollment target
4
Study locations

NCT06939348: Recruiting NA study of Consciousness Disorders and Disorders of Consciousness Due to Severe Brain Injury, sponsored by University of California, Los Angeles.

NCT06939348 is a NA study of Consciousness Disorders and Disorders of Consciousness Due to Severe Brain Injury that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 60 participants, above the 48-participant average among 4 other Consciousness Disorders trials with a reported enrollment target (25% higher). The trial reports 4 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT06939348, a NA study of Consciousness Disorders and Disorders of Consciousness Due to Severe Brain Injury, is actively recruiting participants, sponsored by University of California, Los Angeles.

RECRUITING
Registry status
NA
Development phase
60 participants
Enrollment target
4
Study locations

Study Summary

The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this multicenter project aims to (1) establish short-term efficacy of tFUS as a therapeutic to promote recovery in patients with prolonged DoC as compared to sham treatment, (2) establish dose-related safety and efficacy of tFUS as a therapeutic intervention in prolonged DoC patients and (3) explore preliminary predictors and biomarkers of susceptibility and response to thalamic sonication.

Primary Outcome

Outcome measures collected prior to tFUS/sham sessions will be compared to outcome measures obtained one week after tFUS/sham sessions. The two endpoint measures used will be one DoC-specific measure: the Coma Recovery Scale Revised (CRS-R). The Coma Recovery Scale Revised (CRS-R) ranges from 0 to 23 points, with higher scores indicating better neurological function and level of consciousness. A score of 0 represents the lowest level of neurological functioning, while a score of 23 represents th

Conditions Studied

Consciousness Disorders Disorders of Consciousness Due to Severe Brain Injury

Interventions

  • DEVICE The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.

Study Locations (4)

California

  • The Regents of the University of California, Los Angeles - Los Angeles
  • Casa Colina Hospital and Centers for Healthcare - Pomona

Massachusetts

  • Massachusetts General Hospital (The General Hospital Corp.) - Boston
  • Spaulding Rehabilitation Hospital Corporation, Inc. - Charlestown

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2025-04-26
Est. Completion 2028-09-29
Phase NA
University of California, Los Angeles

897 total trials

What NCT06939348 shows while recruiting

NCT06939348 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, above the 48-participant average among 4 other Consciousness Disorders trials with a reported enrollment target (25% higher).

The record links to 2 conditions, with Consciousness Disorders appearing as the primary indexed condition, and to 1 intervention - of which The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain. is the first listed.

NCT06939348 reports a single indexed study location in California, Massachusetts.

Frequently Asked Questions

What is clinical trial NCT06939348 about?

NCT06939348 is a clinical study titled "Ultrasound Stimulation for Patients in a Disorder of Consciousness". The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this multicenter project aims to (1) establish short-term efficacy of tFUS as a therapeutic to promote recovery in patients with p...

What is the current status of trial NCT06939348?

This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2025-04-26. Estimated completion is 2028-09-29.

What conditions does trial NCT06939348 study?

This clinical trial studies the following conditions: Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury.

What interventions are being tested in trial NCT06939348?

The interventions under investigation include: The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain. (DEVICE).

Who is sponsoring clinical trial NCT06939348?

This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06939348 being conducted?

This trial has 4 study locations across California, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Consciousness Disorders

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT00576069 · 60 participants

    Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma

  • NCT01297400 · 60 participants · Phase 2

    Phase 2 Pilot Study of the Safety and Efficacy of Topical MW-III in Thermal Burns

  • NCT01734122 · 60 participants

    Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor

  • NCT01804634 · 60 participants · Phase 2

    Reduced Intensity Haploidentical BMT for High Risk Solid Tumors

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

More recruiting context for NCT06939348

Source: ClinicalTrials.gov NCT06939348, the US trial registry maintained by the National Library of Medicine. NCT06939348 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.