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NCT06939153 · ClinicalTrials.gov registry record · NA
Effects of Age, Sex and Isometric Exercise on Ventricular-Vascular Interactions During Cardiac Unloading
A NA study of Orthostatic Intolerance, sponsored by Tracy Baynard.
- Recruiting
- Registry status
- NA
- Development phase
- 64
- Enrollment target
- 1
- Study location
NCT06939153 is a NA study of Orthostatic Intolerance that is actively recruiting participants, run by Tracy Baynard. The registered enrollment target is 64 participants, below the 148-participant average among 5 other Orthostatic Intolerance trials with a reported enrollment target (57% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06939153, a NA study of Orthostatic Intolerance, is actively recruiting participants, sponsored by Tracy Baynard.
- RECRUITING
- Registry status
- NA
- Development phase
- 64 participants
- Enrollment target
- 1
- Study location
Study Summary
As people get older, especially women, they often feel dizzy or even faint when they go from sitting or lying down to standing up. This happens because their blood pressure (BP) drops, which can lead to falls, heart problems, and even death in older adults. When BP changes, it affects how well the heart works and how it talks with blood vessels. However, little research has been done on how the heart and blood vessels talk during times of low BP. The crosstalk between the heart and blood vessels is important, as it allows enough blood and oxygen to reach the brain and other vital organs. Some research shows that as we get older, the crosstalk does not work as well. This can make it harder for blood to flow properly or put extra pressure on the heart and arteries. That's why we want to study how the heart and blood vessels talk during a laboratory-simulated situation of low BP in young and older men and women. In our study, participants will lie down with their lower body in a chamber that creates a vacuum around their legs. This safely mimics what happens when you stand up quickly. We can then measure heart function, the stress on arteries, and BP while your legs are in that vacuum. We'll use an ultrasound to check the heart and a finger cuff to measure BP. We'll also see if gripping something firmly can help protect from sudden drops in blood pressure. This study will help us understand more about a condition called orthostatic hypotension and might even suggest that handgrip exercise could prevent it. The main questions the current study aims to address are: * Does the cross-talk between the heart and vessels become more impaired with aging during laboratory-simulated conditions of low BP? * Do women have worse crosstalk between the heart and blood vessels during laboratory-simulated conditions of BP? * Does hand gripping protect against drops in BP during conditions of low BP? All participants will be asked to * Complete two laboratory conditions on two separ
Conditions Studied
Interventions
- OTHER LBNP
- OTHER LBNP + Isometric handgrip exercise
Study Locations (1)
Massachusetts
- University of Massachusetts Boston - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 64 participants |
| Start Date | 2025-05-01 |
| Est. Completion | 2026-01-15 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06939153
The ClinicalTrials.gov registry entry for NCT06939153 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 64 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 148-participant average among 5 other Orthostatic Intolerance trials with a reported enrollment target (57% lower). The listed sponsor is Tracy Baynard, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Orthostatic Intolerance appearing as the primary indexed condition, and to 2 interventions - of which LBNP is the first listed.
NCT06939153 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06939153 about?
NCT06939153 is a clinical study titled "Effects of Age, Sex and Isometric Exercise on Ventricular-Vascular Interactions During Cardiac Unloading". As people get older, especially women, they often feel dizzy or even faint when they go from sitting or lying down to standing up. This happens because their blood pressure (BP) drops, which can lead to falls, heart problems, and even death in older adults. When BP changes, it affects how well the h...
What is the current status of trial NCT06939153?
This trial is currently recruiting. It is a NA study. The enrollment target is 64 participants. The study started on 2025-05-01. Estimated completion is 2026-01-15.
What conditions does trial NCT06939153 study?
This clinical trial studies the following conditions: Orthostatic Intolerance.
What interventions are being tested in trial NCT06939153?
The interventions under investigation include: LBNP (OTHER), LBNP + Isometric handgrip exercise (OTHER).
Who is sponsoring clinical trial NCT06939153?
This trial is sponsored by Tracy Baynard, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06939153 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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