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A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP
NCT06920004 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of this study is to compare empasiprubart and IVIg for treating people with CIDP. This study consists of a Part A where participants will either receive empasiprubart and a placebo resembling IVIg, or IVIg and a placebo resembling empasiprubart for 24 weeks (6 months). Following Part A, participants will enter Part B in which all participants will receive empasiprubart for 96 weeks (24 months). More information can be found here: https://clinicaltrials.argenx.com/emvigorate
Conditions Studied
Interventions
- OTHER IVIg-placebo
- BIOLOGICAL empasiprubart
- BIOLOGICAL IVIg
- OTHER empasiprubart-placebo
Study Locations (20)
Other
- Fakultni nemocnice Brno — Brno
- Astra Kliinik — Tallinn
- Tartu University Hospital — Tartu
- Charité - Universitätsmedizin Berlin — Berlin
- University General Hospital ''ATTIKON'' - General Hospital of West Attica H AGIA VARVARA — Chaïdári
- The Barzilai University Medical Center — Ashkelon
- Hadassah Medical Center- Ein Kerem — Jerusalem
- The Chaim Sheba Medical Center — Tel Litwinsky
- AUSL di Bologna - Ospedale Bellaria — Bologna
- Aomori Prefectural Central Hospital — Aomori
Florida
- Homestead Associates in Research Inc — Homestead
- Visionary Investigators Network — Miami
Michigan
- University of Michigan Hospital — Ann Arbor
- University of Michigan Hospital — Ann Arbor
Texas
- NeuroCarePlus — Houston
- National Neuromuscular Research Institute — Irving
Colorado
- Colorado Springs Neurological Associates — Colorado Springs
District of Columbia
- MedStar Washington Hospital Center — Washington D.C.
Louisiana
- Paradigm Health System — Slidell
Maryland
- Erlanger Health System — Columbia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 218 participants |
| Start Date | 2025-08-22 |
| Est. Completion | 2030-09 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06920004
The ClinicalTrials.gov registry entry for NCT06920004 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 218 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is argenx, which has 96 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Chronic Inflammatory Demyelinating Polyneuropathy appearing as the primary indexed condition, and to 4 interventions — of which IVIg-placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06920004 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, Florida, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06920004 about?
NCT06920004 is a clinical study titled "A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP". The main purpose of this study is to compare empasiprubart and IVIg for treating people with CIDP. This study consists of a Part A where participants will either receive empasiprubart and a placebo resembling IVIg, or IVIg and a placebo resembling empasiprubart for 24 weeks (6 months). Following Par...
What is the current status of trial NCT06920004?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 218 participants. The study started on 2025-08-22. Estimated completion is 2030-09.
What conditions does trial NCT06920004 study?
This clinical trial studies the following conditions: Chronic Inflammatory Demyelinating Polyneuropathy, CIDP, CIDP - Chronic Inflammatory Demyelinating Polyneuropathy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06920004?
The interventions under investigation include: IVIg-placebo (OTHER), empasiprubart (BIOLOGICAL), IVIg (BIOLOGICAL), empasiprubart-placebo (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06920004?
This trial is sponsored by argenx, which has 96 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06920004 being conducted?
This trial has 20 study locations across Colorado, District of Columbia, Florida, Louisiana, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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