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NCT06919991 · ClinicalTrials.gov registry record · Phase 1
Drug-Drug Interaction Study of Casdatifan in Healthy Adult Participants (ARC-29)
A Phase 1 study, sponsored by Arcus Biosciences.
- Completed
- Registry status
- Phase 1
- Development phase
- 14
- Enrollment target
NCT06919991: Completed Phase 1 study, sponsored by Arcus Biosciences.
NCT06919991 is a Phase 1 study that has completed, run by Arcus Biosciences. The registered enrollment target is 14 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (77% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06919991, a Phase 1 study, has completed, sponsored by Arcus Biosciences.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 14 participants
- Enrollment target
Study Summary
The purpose of the study is to assess the effects of multiple doses of itraconazole (a strong CYP3A4 inhibitor) on single dose PK of casdatifan in healthy adults and to assess the effects of multiple doses of phenytoin (a strong CYP3A4 inducer) on single dose PK of casdatifan in healthy adults.
Interventions
- DRUG Itraconazole
- DRUG Casdatifan
- DRUG Phenytoin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2025-05-02 |
| Est. Completion | 2025-10-18 |
| Phase | Phase 1 |
What the finished NCT06919991 record still lists
NCT06919991 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (77% lower).
The record links to 0 conditions, and to 3 interventions - of which Itraconazole is the first listed.
NCT06919991 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06919991 about?
NCT06919991 is a clinical study titled "Drug-Drug Interaction Study of Casdatifan in Healthy Adult Participants (ARC-29)". The purpose of the study is to assess the effects of multiple doses of itraconazole (a strong CYP3A4 inhibitor) on single dose PK of casdatifan in healthy adults and to assess the effects of multiple doses of phenytoin (a strong CYP3A4 inducer) on single dose PK of casdatifan in healthy adults.
What is the current status of trial NCT06919991?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 14 participants. The study started on 2025-05-02. Estimated completion is 2025-10-18.
What interventions are being tested in trial NCT06919991?
The interventions under investigation include: Itraconazole (DRUG), Casdatifan (DRUG), Phenytoin (DRUG).
Who is sponsoring clinical trial NCT06919991?
This trial is sponsored by Arcus Biosciences, which has 25 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06919991's enrollment target sits among peer trials
14 1844th of 2000 higher than 154 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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