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NCT06894745 · ClinicalTrials.gov registry record · Phase 1
PET [89Zr]DFO-starPEG in Solid Tumors
A Phase 1 study of Solid Tumor and Solid Carcinoma, sponsored by Robert Flavell, MD, PhD.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 13
- Enrollment target
- 1
- Study location
NCT06894745: Recruiting Phase 1 study of Solid Tumor and Solid Carcinoma, sponsored by Robert Flavell, MD, PhD.
NCT06894745 is a Phase 1 study of Solid Tumor and Solid Carcinoma that is actively recruiting participants, run by Robert Flavell, MD, PhD. The registered enrollment target is 13 participants, below the 222-participant average among 196 other Solid Tumor trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06894745, a Phase 1 study of Solid Tumor and Solid Carcinoma, is actively recruiting participants, sponsored by Robert Flavell, MD, PhD.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 13 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a first-in-human, pilot study of the novel PET-imaging radiotracer \[89Zr\]DFO-starPEG. The study is designed to obtain preliminary data to support future development of this agent as an imaging surrogate to visualize enhanced permeability and retention (EPR)-mediated tracer uptake before administration of EPR-based nanomedicines.
Primary Outcome
The median and range for intra-tumoral SUVmax within metastatic lesions will be descriptively reported, to assess for intra-tumoral heterogeneity and differences in uptake by site of disease.
Conditions Studied
Interventions
- PROCEDURE Specimen Collection
- DRUG 89-zr-dfo-star polyethylene glycol (StarPEG)
- PROCEDURE Whole Body Positron Emission Tomography (PET)
Study Locations (1)
California
- University of California, San Francisco - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2025-06-02 |
| Est. Completion | 2027-12-31 |
| Phase | Phase 1 |
What NCT06894745 shows while recruiting
NCT06894745 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 13 participants, a relatively small participant target, below the 222-participant average among 196 other Solid Tumor trials with a reported enrollment target (94% lower).
The record links to 3 conditions, with Solid Tumor appearing as the primary indexed condition, and to 3 interventions - of which Specimen Collection is the first listed.
NCT06894745 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06894745 about?
NCT06894745 is a clinical study titled "PET [89Zr]DFO-starPEG in Solid Tumors". This is a first-in-human, pilot study of the novel PET-imaging radiotracer \[89Zr\]DFO-starPEG. The study is designed to obtain preliminary data to support future development of this agent as an imaging surrogate to visualize enhanced permeability and retention (EPR)-mediated tracer uptake before ad...
What is the current status of trial NCT06894745?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 13 participants. The study started on 2025-06-02. Estimated completion is 2027-12-31.
What conditions does trial NCT06894745 study?
This clinical trial studies the following conditions: Solid Tumor, Solid Carcinoma, Soft Tissue Lesion.
What interventions are being tested in trial NCT06894745?
The interventions under investigation include: Specimen Collection (PROCEDURE), 89-zr-dfo-star polyethylene glycol (StarPEG) (DRUG), Whole Body Positron Emission Tomography (PET) (PROCEDURE).
Who is sponsoring clinical trial NCT06894745?
This trial is sponsored by Robert Flavell, MD, PhD, which has 5 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06894745 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Solid Tumor
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06894745's enrollment target sits among peer trials
13 189th of 196 higher than 8 of 196 other Solid Tumor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Solid Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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A Study Investigating BGB-26808 Alone or in Combination With Tislelizumab in Participants With Advanced Solid Tumors
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