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NCT06894004 · ClinicalTrials.gov registry record · NA
Mechanism of Ketogenic Diet-Induced Hypercholesterolemia
A NA study of Hypercholesterolemia and Hyperlipidemia, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT06894004: Recruiting NA study of Hypercholesterolemia and Hyperlipidemia, sponsored by Washington University School of Medicine.
NCT06894004 is a NA study of Hypercholesterolemia and Hyperlipidemia that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 100 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06894004, a NA study of Hypercholesterolemia and Hyperlipidemia, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.
Primary Outcome
Determined by using plasma and VLDL-ApoB100 leucine isotopic enrichment and compartmental modeling
Conditions Studied
Interventions
- BEHAVIORAL Ketogenic Diet
- BEHAVIORAL Control Diet
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-02-24 |
| Est. Completion | 2030-11-30 |
| Phase | NA |
What NCT06894004 shows while recruiting
NCT06894004 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Hypercholesterolemia and Hyperlipidemia appearing as the primary indexed condition, and to 2 interventions - of which Ketogenic Diet is the first listed.
NCT06894004 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT06894004 about?
NCT06894004 is a clinical study titled "Mechanism of Ketogenic Diet-Induced Hypercholesterolemia". Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will...
What is the current status of trial NCT06894004?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2025-02-24. Estimated completion is 2030-11-30.
What conditions does trial NCT06894004 study?
This clinical trial studies the following conditions: Hypercholesterolemia and Hyperlipidemia.
What interventions are being tested in trial NCT06894004?
The interventions under investigation include: Ketogenic Diet (BEHAVIORAL), Control Diet (BEHAVIORAL).
Who is sponsoring clinical trial NCT06894004?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06894004 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06894004's enrollment target sits among peer trials
100 841st of 2000 higher than 1,081 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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