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NCT06865170 · ClinicalTrials.gov registry record · Phase 4
Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?
A Phase 4 study, sponsored by University of California, Davis.
- Not yet
- Registry status
- Phase 4
- Development phase
- 88
- Enrollment target
NCT06865170: Clinical Trial Phase 4 study, sponsored by University of California, Davis.
NCT06865170 is a Phase 4 study that has not yet begun recruiting, run by University of California, Davis. The registered enrollment target is 88 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (83% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06865170, a Phase 4 study, has not yet begun recruiting, sponsored by University of California, Davis.
- NOT YET RECRUITING
- Registry status
- Phase 4
- Development phase
- 88 participants
- Enrollment target
Study Summary
This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence or absence of topical ethyl chloride spray. Additionally, this study will investigate the effects of other various factors on patients' pain associated with the injection. Lastly, this study aims to determine the effect of patients' subjective pain from the injection on long-term clinical outcomes. Specific aims are as follows: Aim 1): Determine the effect of needle gauge size on patient reported pain associated with an ultrasound-guided intra-articular knee injection. Aim 2): Determine the effect of ethyl chloride spray on patient reported pain associated with an ultrasound-guided intra-articular knee injection. Aim 3): Determine the effect of sex, age, BMI, thigh size, severity of OA, and fear of needles on patient pain associated with an ultrasound-guided intra-articular knee injection. Aim 4) Determine the effect of patient pain from the procedure on longer term clinical outcomes after an ultrasound-guided intra-articular knee steroid injection. Researchers will obtain data at various time points, including pre-procedural data, immediately after the procedure, 24-48 hours after, and 6 weeks post-procedure. Participants will: Consent to receiving an intra-articular knee joint injection with steroids if indicated. Score their "procedural" pain immediately following the procedure, score their post-procedural "soreness" 24-48 hours after via telephone call, and score their overall knee pain about 6 weeks after the procedure via telephone call.
Primary Outcome
NRPS = "Numeric Rating of Pain Scale", scale from 0 to 100. "0" = minimum score, better outcome); "100" (maximum score, worse outcome)
Interventions
- PROCEDURE 25 gauge needle
- PROCEDURE 22 gauge needle
- PROCEDURE +/- Ethyl Chloride Topical Aerosol Anesthetic
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 88 participants |
| Start Date | 2026-08 |
| Est. Completion | 2026-12 |
| Phase | Phase 4 |
What is known before NCT06865170 opens enrollment
NCT06865170 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 88 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (83% lower).
The record links to 0 conditions, and to 3 interventions - of which 25 gauge needle is the first listed.
NCT06865170 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06865170 about?
NCT06865170 is a clinical study titled "Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?". This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence or absence of topical ethyl chloride spray. Additionally, this study w...
What is the current status of trial NCT06865170?
This trial is currently not yet recruiting. It is a Phase 4 study. The enrollment target is 88 participants. The study started on 2026-08. Estimated completion is 2026-12.
What interventions are being tested in trial NCT06865170?
The interventions under investigation include: 25 gauge needle (PROCEDURE), 22 gauge needle (PROCEDURE), +/- Ethyl Chloride Topical Aerosol Anesthetic (PROCEDURE).
Who is sponsoring clinical trial NCT06865170?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06865170's enrollment target sits among peer trials
88 916th of 2000 higher than 1,078 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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