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NCT06831071 · ClinicalTrials.gov registry record
Evaluation of Hypoxia in Primary Melanoma
A clinical trial of Melanoma, sponsored by Yana Najjar.
- Recruiting
- Registry status
- 50
- Enrollment target
- 1
- Study location
NCT06831071: Recruiting study of Melanoma, sponsored by Yana Najjar.
NCT06831071 is a study of Melanoma that is actively recruiting participants, run by Yana Najjar. The registered enrollment target is 50 participants, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06831071, a study of Melanoma, is actively recruiting participants, sponsored by Yana Najjar.
- RECRUITING
- Registry status
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
When controlling for tumor present in the Sentinel lymph node (SLN), intranodal hypoxia, as measured by Carbonic Anhydrase IX (CAIX IHC), is associated with worse PFS. This suggests that melanoma tumors may be utilizing deregulated metabolism as a means of propagating themselves to the next station of metastasis. This study aims to prospectively validate previous findings. Patients who are to undergo WLE and SLNB per standard of care (SOC) will be evaluable. It is hypothesized that SLN(s) with increased hypoxia, as measured by pimonidazole staining, will be associated with worse Progression-free Survival (PFS).
Primary Outcome
Hypoxia (decreased oxygen levels) in the primary tumor in patients with primary melanoma as measured by hypoxyprobe staining in primary tumor through CODEX imaging.
Conditions Studied
Interventions
- DRUG Pimonidazole
Study Locations (1)
Pennsylvania
- UPMC Hillman Cancer Center - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-04-09 |
| Est. Completion | 2027-03-31 |
What NCT06831071 shows while recruiting
NCT06831071 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Melanoma appearing as the primary indexed condition, and to 1 intervention - of which Pimonidazole is the first listed.
NCT06831071 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06831071 about?
NCT06831071 is a clinical study titled "Evaluation of Hypoxia in Primary Melanoma". When controlling for tumor present in the Sentinel lymph node (SLN), intranodal hypoxia, as measured by Carbonic Anhydrase IX (CAIX IHC), is associated with worse PFS. This suggests that melanoma tumors may be utilizing deregulated metabolism as a means of propagating themselves to the next station ...
What is the current status of trial NCT06831071?
This trial is currently recruiting. The enrollment target is 50 participants. The study started on 2025-04-09. Estimated completion is 2027-03-31.
What conditions does trial NCT06831071 study?
This clinical trial studies the following conditions: Melanoma.
What interventions are being tested in trial NCT06831071?
The interventions under investigation include: Pimonidazole (DRUG).
Who is sponsoring clinical trial NCT06831071?
This trial is sponsored by Yana Najjar, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06831071 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06831071's enrollment target sits among peer trials
50 163rd of 266 higher than 99 of 266 other Melanoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Melanoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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