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NCT06771583 · ClinicalTrials.gov registry record
Identification and Validation of Epigenetic Biomarkers of PMDD
A clinical trial of Premenstrual Syndrome and Menstrual Cycle, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- 500
- Enrollment target
- 1
- Study location
NCT06771583 is a study of Premenstrual Syndrome and Menstrual Cycle that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 500 participants, above the 52-participant average among 6 other Premenstrual Syndrome trials with a reported enrollment target (862% higher). The trial reports 1 study location across 1 state.
The verdict
NCT06771583, a study of Premenstrual Syndrome and Menstrual Cycle, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- 500 participants
- Enrollment target
- 1
- Study location
Study Summary
This research is being done to examine epigenetic markers and mood changes across the menstrual cycle, particularly in premenstrual dysphoric disorder (PMDD). The investigators previously identified epigenetic biomarkers of postpartum depression, another reproductive affective disorder, and in this study aim to determine if these biomarkers also distinguish PMDD cases from healthy controls at different points in the menstrual cycle. By collecting biological samples (such as blood) and monitoring mood changes across the menstrual cycle, the investigators will be able to determine whether these epigenetic markers are associated with PMDD. The investigators plan to study these epigenetic markers during the follicular phase (roughly the first half of the menstrual cycle, from menses until ovulation) and the luteal phase (roughly the second half of the menstrual cycle, from ovulation to menses). The investigators will study this in two groups: 1) individuals who do NOT have premenstrual mood symptoms, and 2) individuals with premenstrual syndrome/premenstrual dysphoric disorder (PMS/PMDD). The results will provide a comprehensive view of the changes in these systems across the menstrual cycle. This will add to the investigators understanding of the mechanisms that may cause PMS/PMDD.
Conditions Studied
Study Locations (1)
Maryland
- Johns Hopkins Reproductive Mental Health Center - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 500 participants |
| Start Date | 2025-09-12 |
| Est. Completion | 2031-02-15 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06771583
The ClinicalTrials.gov registry entry for NCT06771583 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 500 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 52-participant average among 6 other Premenstrual Syndrome trials with a reported enrollment target (862% higher). The listed sponsor is Johns Hopkins University, which has 1,448 total studies on file at ClinicalTrials.gov.
The record links to 5 conditions, with Premenstrual Syndrome appearing as the primary indexed condition, and to 0 interventions.
NCT06771583 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT06771583 about?
NCT06771583 is a clinical study titled "Identification and Validation of Epigenetic Biomarkers of PMDD". This research is being done to examine epigenetic markers and mood changes across the menstrual cycle, particularly in premenstrual dysphoric disorder (PMDD). The investigators previously identified epigenetic biomarkers of postpartum depression, another reproductive affective disorder, and in this ...
What is the current status of trial NCT06771583?
This trial is currently recruiting. The enrollment target is 500 participants. The study started on 2025-09-12. Estimated completion is 2031-02-15.
What conditions does trial NCT06771583 study?
This clinical trial studies the following conditions: Premenstrual Syndrome, Menstrual Cycle, Premenstrual Dysphoric Disorder (PMDD), PMDD, Premenstrual Syndrome-PMS.
Who is sponsoring clinical trial NCT06771583?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06771583 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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