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NCT06695884 · ClinicalTrials.gov registry record · NA
Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity
A NA study of Nicotine Use Disorder, sponsored by Rutgers, The State University of New Jersey.
- Recruiting
- Registry status
- NA
- Development phase
- 42
- Enrollment target
- 1
- Study location
NCT06695884: Recruiting NA study of Nicotine Use Disorder, sponsored by Rutgers, The State University of New Jersey.
NCT06695884 is a NA study of Nicotine Use Disorder that is actively recruiting participants, run by Rutgers, The State University of New Jersey. The registered enrollment target is 42 participants, below the 97-participant average among 7 other Nicotine Use Disorder trials with a reported enrollment target (57% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06695884, a NA study of Nicotine Use Disorder, is actively recruiting participants, sponsored by Rutgers, The State University of New Jersey.
- RECRUITING
- Registry status
- NA
- Development phase
- 42 participants
- Enrollment target
- 1
- Study location
Study Summary
The primary goal will be to identify the optimal pulse protocol by systematically measuring the efficacy of various theta burst stimulation and repetitive rTMS protocols to increase and decrease the reward positivity in dependent smokers. The secondary objective will be to measure the protocols' effectiveness to increase decision-making capacity using the probabilistic selection task (PST). The third objective will be to specifically assess whether the TMS targets has a differential impact on state levels of craving relative to baseline (Tobacco Craving Questionnaire \[TCQ\]. The investigators plan to accomplish these three objectives using a randomized, controlled experiment involving 2 sessions.
Primary Outcome
The reward positivity is an event-related brain potential (ERP) sensitive to reward feedback. The reward positivity will be measured during the T-maze task, where participants will receive feedback (Reward, No-reward) following choices. ERPs will be created for each electrode and participant by averaging the single-trial EEG according to feedback type (Reward, No-reward). The reward positivity will be evaluated by subtracting the Reward feedback ERPs from the corresponding No-reward feedback ERP
Conditions Studied
Interventions
- DEVICE Transcranial Magnetic Stimulation
Study Locations (1)
New Jersey
- Rutgers University - Newark - Newark
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2024-08-01 |
| Est. Completion | 2026-08-31 |
| Phase | NA |
What NCT06695884 shows while recruiting
NCT06695884 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 42 participants, a relatively small participant target, below the 97-participant average among 7 other Nicotine Use Disorder trials with a reported enrollment target (57% lower).
The record links to 1 condition, with Nicotine Use Disorder appearing as the primary indexed condition, and to 1 intervention - of which Transcranial Magnetic Stimulation is the first listed.
NCT06695884 reports a single indexed study location in New Jersey.
Frequently Asked Questions
What is clinical trial NCT06695884 about?
NCT06695884 is a clinical study titled "Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity". The primary goal will be to identify the optimal pulse protocol by systematically measuring the efficacy of various theta burst stimulation and repetitive rTMS protocols to increase and decrease the reward positivity in dependent smokers. The secondary objective will be to measure the protocols' eff...
What is the current status of trial NCT06695884?
This trial is currently recruiting. It is a NA study. The enrollment target is 42 participants. The study started on 2024-08-01. Estimated completion is 2026-08-31.
What conditions does trial NCT06695884 study?
This clinical trial studies the following conditions: Nicotine Use Disorder.
What interventions are being tested in trial NCT06695884?
The interventions under investigation include: Transcranial Magnetic Stimulation (DEVICE).
Who is sponsoring clinical trial NCT06695884?
This trial is sponsored by Rutgers, The State University of New Jersey, which has 413 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06695884 being conducted?
This trial has 1 study location across New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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