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NCT06694441 · ClinicalTrials.gov registry record · NA

Noradrenergic Dysregulation, Sleep and Cognition in Older Adults with Insomnia

A NA study of Insomnia, sponsored by Northwestern University.

Recruiting
Registry status
NA
Development phase
60
Enrollment target
1
Study location

NCT06694441 is a NA study of Insomnia that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 60 participants, below the 170-participant average among 151 other Insomnia trials with a reported enrollment target (65% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06694441, a NA study of Insomnia, is actively recruiting participants, sponsored by Northwestern University.

RECRUITING
Registry status
NA
Development phase
60 participants
Enrollment target
1
Study location

Study Summary

This study investigates the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia - a population at elevated risk for Alzheimer's disease-related dementias (ADRD) - compared to age and sex matched controls with normal sleep. The study characterizes NA function through multiple approaches: measuring 24-hour plasma levels of norepinephrine (NE) and its brain metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG); evaluating central NA system response using the clonidine suppression test (a presynaptic α2 adrenoreceptor agonist that reduces locus coeruleus NA activity; and employing pupillometry as a non-invasive marker of autonomic function. To explore NA function's mechanistic role in insomnia, the study uses an intervention with bright light exposure to enhance daytime NA activity, with the goal of improving both sleep quality and cognitive performance.

Conditions Studied

Insomnia

Interventions

  • OTHER Placebo
  • OTHER Light Exposure

Study Locations (1)

Illinois

  • Northwestern University Feinberg School of Medicine, Center for Circadian and Sleep Medicine - Chicago

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2024-09-30
Est. Completion 2029-08-31
Phase NA

Sponsor

Northwestern University

1,209 total trials

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What the Registry Record Tells You About NCT06694441

The ClinicalTrials.gov registry entry for NCT06694441 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 170-participant average among 151 other Insomnia trials with a reported enrollment target (65% lower). The listed sponsor is Northwestern University, which has 1,209 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Insomnia appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT06694441 reports 1 study location spanning 1 distinct geographic area - top geographies include Illinois.

Frequently Asked Questions

What is clinical trial NCT06694441 about?

NCT06694441 is a clinical study titled "Noradrenergic Dysregulation, Sleep and Cognition in Older Adults with Insomnia". This study investigates the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia - a population at elevated risk for Alzheimer's disease-related dementias (ADRD) - compared to age and sex matched controls with normal sleep. The study...

What is the current status of trial NCT06694441?

This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2024-09-30. Estimated completion is 2029-08-31.

What conditions does trial NCT06694441 study?

This clinical trial studies the following conditions: Insomnia.

What interventions are being tested in trial NCT06694441?

The interventions under investigation include: Placebo (OTHER), Light Exposure (OTHER).

Who is sponsoring clinical trial NCT06694441?

This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06694441 being conducted?

This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.