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NCT06694441 · ClinicalTrials.gov registry record · NA
Noradrenergic Dysregulation, Sleep and Cognition in Older Adults with Insomnia
A NA study of Insomnia, sponsored by Northwestern University.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06694441: Recruiting NA study of Insomnia, sponsored by Northwestern University.
NCT06694441 is a NA study of Insomnia that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 60 participants, below the 170-participant average among 151 other Insomnia trials with a reported enrollment target (65% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06694441, a NA study of Insomnia, is actively recruiting participants, sponsored by Northwestern University.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
This study investigates the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia - a population at elevated risk for Alzheimer's disease-related dementias (ADRD) - compared to age and sex matched controls with normal sleep. The study characterizes NA function through multiple approaches: measuring 24-hour plasma levels of norepinephrine (NE) and its brain metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG); evaluating central NA system response using the clonidine suppression test (a presynaptic α2 adrenoreceptor agonist that reduces locus coeruleus NA activity; and employing pupillometry as a non-invasive marker of autonomic function. To explore NA function's mechanistic role in insomnia, the study uses an intervention with bright light exposure to enhance daytime NA activity, with the goal of improving both sleep quality and cognitive performance.
Primary Outcome
24-h plasma norepinephrine (pg/mL) collected every two hours
Conditions Studied
Interventions
- OTHER Placebo
- OTHER Light Exposure
Study Locations (1)
Illinois
- Northwestern University Feinberg School of Medicine, Center for Circadian and Sleep Medicine - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-09-30 |
| Est. Completion | 2029-08-31 |
| Phase | NA |
What NCT06694441 shows while recruiting
NCT06694441 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 170-participant average among 151 other Insomnia trials with a reported enrollment target (65% lower).
The record links to 1 condition, with Insomnia appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06694441 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06694441 about?
NCT06694441 is a clinical study titled "Noradrenergic Dysregulation, Sleep and Cognition in Older Adults with Insomnia". This study investigates the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia - a population at elevated risk for Alzheimer's disease-related dementias (ADRD) - compared to age and sex matched controls with normal sleep. The study...
What is the current status of trial NCT06694441?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2024-09-30. Estimated completion is 2029-08-31.
What conditions does trial NCT06694441 study?
This clinical trial studies the following conditions: Insomnia.
What interventions are being tested in trial NCT06694441?
The interventions under investigation include: Placebo (OTHER), Light Exposure (OTHER).
Who is sponsoring clinical trial NCT06694441?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06694441 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Insomnia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06694441's enrollment target sits among peer trials
60 89th of 151 higher than 58 of 151 other Insomnia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Insomnia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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