Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT06681844 · ClinicalTrials.gov registry record

Predict Tooth Wear

A clinical trial of Prediction of Tooth Wear, sponsored by Hospices Civils de Lyon.

Recruiting
Registry status
1,000
Enrollment target
5
Study locations

NCT06681844: Recruiting study of Prediction of Tooth Wear, sponsored by Hospices Civils de Lyon.

NCT06681844 is a study of Prediction of Tooth Wear that is actively recruiting participants, run by Hospices Civils de Lyon. The registered enrollment target is 1,000 participants. The trial reports 5 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT06681844, a study of Prediction of Tooth Wear, is actively recruiting participants, sponsored by Hospices Civils de Lyon.

RECRUITING
Registry status
1,000 participants
Enrollment target
5
Study locations

Study Summary

Tooth wear, resulting from gradual loss of dental hard tissue due to mechanical and chemical factors, impacts tooth structure, texture, and function. It affects quality of life, with varying prevalence (26.9% to 90.0%), and is traditionally detected visually during check-ups, often at advanced stages. Monitoring alterations in tooth shape via intraoral scanners aids early detection, but restoration remains challenging. Prevention through early detection is vital, as patients may not fully comprehend tooth structure loss until visible. Recently, statistical shape analysis (SSA) used to learn the tooth anatomy and define a reference shape (biogeneric tooth) using. However, assuring landmark consistency is challenging mostly due to biases of the operator. Recently, a robust method called MEG-IsoQuad offered automated, isotopological remeshing. Combining this with SSA holds promise for diagnostic and simulation purposes. This study aims to assess the reliability of a remeshing-SSA approach for altered and intact premolar analysis and compare machine learning algorithms for simulating the shape of the initially intact tooth or future altered one. The clinical perspective of the current work offers possibilities to: * Prevent future tooth wear by detecting it at an early stage; and communicate better to the patient by presenting him/her potential future altered teeth * Simulate the adapted reconstruction for the altered tooth by simulating the initially intact one

Primary Outcome

Four machine learning (ML) algorithms: a linear discriminant analysis (LDA) a support vector machine (SVM), a random forest (RM) and a gradient boosting machine (GBM) will be used to predict the tooth type and the alteration of the anatomy. The data set will be split into a 60/40 train and holdout test data set and models will be three-fold cross validated. Model performances will be evaluated in confusion matrices leading to define precision, recall, F1 score and accuracy.

Conditions Studied

Interventions

  • OTHER Tooth Shape assessed using an intraoral scanner one after avulsion

Study Locations (5)

Other

  • KU Leuven University Hospital - Leuven
  • Lyon Dental Hospital - Lyon
  • King George Medical University - Lucknow
  • Tel Aviv Universi - Tel Aviv

Indiana

  • Indiana University Hospital - Indianapolis

Trial Details

FieldValue
Enrollment Target 1,000 participants
Start Date 2023-12-12
Est. Completion 2027-12
Hospices Civils de Lyon

2 total trials

What NCT06681844 shows while recruiting

NCT06681844 is an observational study that tracks outcomes without assigning an intervention. Its 1,000 participants enrollment target places it among the larger protocols in the corpus.

The record links to 1 condition, with Prediction of Tooth Wear appearing as the primary indexed condition, and to 1 intervention - of which Tooth Shape assessed using an intraoral scanner one after avulsion is the first listed.

NCT06681844 lists 5 locations in 2 states (Other, Indiana).

Frequently Asked Questions

What is clinical trial NCT06681844 about?

NCT06681844 is a clinical study titled "Predict Tooth Wear". Tooth wear, resulting from gradual loss of dental hard tissue due to mechanical and chemical factors, impacts tooth structure, texture, and function. It affects quality of life, with varying prevalence (26.9% to 90.0%), and is traditionally detected visually during check-ups, often at advanced stage...

What is the current status of trial NCT06681844?

This trial is currently recruiting. The enrollment target is 1,000 participants. The study started on 2023-12-12. Estimated completion is 2027-12.

What conditions does trial NCT06681844 study?

This clinical trial studies the following conditions: Prediction of Tooth Wear.

What interventions are being tested in trial NCT06681844?

The interventions under investigation include: Tooth Shape assessed using an intraoral scanner one after avulsion (OTHER).

Who is sponsoring clinical trial NCT06681844?

This trial is sponsored by Hospices Civils de Lyon, which has 2 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06681844 being conducted?

This trial has 5 study locations across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT00018044 · 1,000 participants

    Study of Mycobacterial Infections

  • NCT01036581 · 1,000 participants · NA

    Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

  • NCT01192048 · 1,000 participants

    Genetics of Congenital Heart Disease

  • NCT01553214 · 1,000 participants · Phase 4

    Improving White Blood Cell Collection From Healthy Donors

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

Source: ClinicalTrials.gov NCT06681844, the US trial registry maintained by the National Library of Medicine. NCT06681844 (large enrollment · multi site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.