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NCT06681129 · ClinicalTrials.gov registry record
Study of Normal Intestinal Development and Disease in Premature and Term Neonates
A clinical trial, sponsored by Boston Children's Hospital.
- Recruiting
- Registry status
- 100
- Enrollment target
NCT06681129: Recruiting study, sponsored by Boston Children's Hospital.
NCT06681129 is a clinical trial that is actively recruiting participants, run by Boston Children's Hospital. The registered enrollment target is 100 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06681129 is actively recruiting participants, sponsored by Boston Children's Hospital.
- RECRUITING
- Registry status
- 100 participants
- Enrollment target
Study Summary
Current research on early intestinal development is primarily performed in mouse models. While useful in many other ways, mouse models are not ideal for studying human intestine development as the timing of this process differs between the two species. Further, prior research has demonstrated that some proteins and pathways that are critical in human development have no clear role in mice. This study aims to improve the overall understanding of critical aspects of intestinal development in humans. In addition, this study will investigate the impact of intestinal diseases that are found in the early stages of life such as necrotizing enterocolitis (NEC).
Primary Outcome
Small intestinal biopsy specimens will be collected either from discarded surgical biopsies collected for clinical reasons or from 1-2 additional small bunch biopsies (5mm) near the surgery site. The tissue will be used to 1.) generate organoids for longitudinal cell culture, 2.) analyze RNA or protein components by transcriptomic or cellular analyses or 3.) analyze histology. We do not have discrete planned outcomes because this is an investigational study and we are looking for new trends or d
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-03-17 |
| Est. Completion | 2034-12-31 |
What NCT06681129 shows while recruiting
NCT06681129 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT06681129 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06681129 about?
NCT06681129 is a clinical study titled "Study of Normal Intestinal Development and Disease in Premature and Term Neonates". Current research on early intestinal development is primarily performed in mouse models. While useful in many other ways, mouse models are not ideal for studying human intestine development as the timing of this process differs between the two species. Further, prior research has demonstrated that s...
What is the current status of trial NCT06681129?
This trial is currently recruiting. The enrollment target is 100 participants. The study started on 2025-03-17. Estimated completion is 2034-12-31.
Who is sponsoring clinical trial NCT06681129?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
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