Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06669650 · ClinicalTrials.gov registry record · Phase 4
Personalized Post-Operative Pain Management
A Phase 4 study of Post-surgical Pain and Persistent Post Operative Opioid Use, sponsored by University of Tennessee Graduate School of Medicine.
- Active
- Registry status
- Phase 4
- Development phase
- 208
- Enrollment target
- 1
- Study location
NCT06669650: Active Phase 4 study of Post-surgical Pain and Persistent Post Operative Opioid Use, sponsored by University of Tennessee Graduate School of Medicine.
NCT06669650 is a Phase 4 study of Post-surgical Pain and Persistent Post Operative Opioid Use that is active but no longer recruiting, run by University of Tennessee Graduate School of Medicine. The registered enrollment target is 208 participants, above the 179-participant average among 7 other Post-surgical Pain trials with a reported enrollment target (16% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06669650, a Phase 4 study of Post-surgical Pain and Persistent Post Operative Opioid Use, is active but no longer recruiting, sponsored by University of Tennessee Graduate School of Medicine.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 4
- Development phase
- 208 participants
- Enrollment target
- 1
- Study location
Study Summary
The main questions this study aims to answer are: Does perioperative PGx personalized opiate therapy reduce persistent post-operative opioid use dependency, improve pain management and reduce opiate related adverse events in opioid naïve patients after surgery? Participants will: Take hydromorphone if the PGx results determine they have a SNP indicating high or low metabolic activity in the CYP2D6 enzyme. Complete a 7-day pain diary post-discharge. Complete a follow-up phone call once per month for 90 days.
Primary Outcome
To determine the overall difference in the number of post-operative opioid prescriptions in 90 days using PGx guided post operative medication
Conditions Studied
Interventions
- DRUG Oxycodone
- DRUG Hydromorphone
- OTHER PGx guided personalized post-operative pain management
Study Locations (1)
Tennessee
- The University of Tennessee Graduate School of Medicine - Knoxville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 208 participants |
| Start Date | 2024-09-25 |
| Est. Completion | 2025-12 |
| Phase | Phase 4 |
What the registry record for NCT06669650 still lists
NCT06669650 is an interventional study that assigns participants to a tested intervention. The registered 208 participants enrollment target is mid-sized for trials with a published cap, above the 179-participant average among 7 other Post-surgical Pain trials with a reported enrollment target (16% higher).
The record links to 2 conditions, with Post-surgical Pain appearing as the primary indexed condition, and to 3 interventions - of which Oxycodone is the first listed.
NCT06669650 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT06669650 about?
NCT06669650 is a clinical study titled "Personalized Post-Operative Pain Management". The main questions this study aims to answer are: Does perioperative PGx personalized opiate therapy reduce persistent post-operative opioid use dependency, improve pain management and reduce opiate related adverse events in opioid naïve patients after surgery? Participants will: Take hydromorpho...
What is the current status of trial NCT06669650?
This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 208 participants. The study started on 2024-09-25. Estimated completion is 2025-12.
What conditions does trial NCT06669650 study?
This clinical trial studies the following conditions: Post-surgical Pain, Persistent Post Operative Opioid Use.
What interventions are being tested in trial NCT06669650?
The interventions under investigation include: Oxycodone (DRUG), Hydromorphone (DRUG), PGx guided personalized post-operative pain management (OTHER).
Who is sponsoring clinical trial NCT06669650?
This trial is sponsored by University of Tennessee Graduate School of Medicine, which has 20 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06669650 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Post-surgical Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Effects of Catheter Location on Postoperative Analgesia for Continuous Adductor Canal and Popliteal-Sciatic Nerve Blocks
COMPLETED · Phase 4
-
TAP-patients With Robotic Assisted Lap Prostatectomy
COMPLETED · Phase 4
-
Dose Response Study of Dexamethasone in Combination With Bupivacaine 0.25%
COMPLETED · NA
-
Recovery Toolkits: Assessment of Pragmatic Behavioral Pain Medicine Delivered In Hospital After Surgery
COMPLETED
-
Characterization of PostOp Pain in Shoulder and Knee Arthroscopy
COMPLETED
-
Study in Subjects Undergoing Complete Abdominoplasty
COMPLETED · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03465774 · 208 participants
Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions
- NCT03803332 · 208 participants · NA
A Trial Comparing Interpersonal Therapy to Exposure Therapy for PTSD Due to Military Sexual Trauma (MST) in Male and Female Military Personnel
- NCT04732065 · 208 participants · Phase 1
ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors
- NCT05293756 · 208 participants · NA
OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP)
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI