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NCT06649955 · ClinicalTrials.gov registry record · NA

Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study

A NA study of ALS (Amyotrophic Lateral Sclerosis), sponsored by PathMaker Neurosystems.

Recruiting
Registry status
NA
Development phase
15
Enrollment target
1
Study location

NCT06649955 is a NA study of ALS (Amyotrophic Lateral Sclerosis) that is actively recruiting participants, run by PathMaker Neurosystems. The registered enrollment target is 15 participants, below the 365-participant average among 6 other ALS (Amyotrophic Lateral Sclerosis) trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06649955, a NA study of ALS (Amyotrophic Lateral Sclerosis), is actively recruiting participants, sponsored by PathMaker Neurosystems.

RECRUITING
Registry status
NA
Development phase
15 participants
Enrollment target
1
Study location

Study Summary

Following completion of the ALS Early Feasibility Study of the MyoRegulator® device for treatment of ALS (NCT06165172), the CALM study will further assess the feasibility of the MyoRegulator® device to treat ALS in an expanded number of individuals with ALS. CALM will gather additional preliminary evidence of clinical safety and potential effectiveness in this patient population with a longer follow-up period and additional secondary endpoints in a single-arm study prior to commencing a larger sham-controlled pivotal trial.

Conditions Studied

ALS (Amyotrophic Lateral Sclerosis)

Interventions

  • DEVICE Multi-site direct current stimulation (DCS)

Study Locations (1)

Massachusetts

  • Beth Israel Deaconess Medical Center - Boston

Trial Details

FieldValue
Enrollment Target 15 participants
Start Date 2025-02-10
Est. Completion 2026-11
Phase NA

Sponsor

PathMaker Neurosystems

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06649955

The ClinicalTrials.gov registry entry for NCT06649955 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 365-participant average among 6 other ALS (Amyotrophic Lateral Sclerosis) trials with a reported enrollment target (96% lower). The listed sponsor is PathMaker Neurosystems, which has 3 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with ALS (Amyotrophic Lateral Sclerosis) appearing as the primary indexed condition, and to 1 intervention - of which Multi-site direct current stimulation (DCS) is the first listed.

NCT06649955 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.

Frequently Asked Questions

What is clinical trial NCT06649955 about?

NCT06649955 is a clinical study titled "Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study". Following completion of the ALS Early Feasibility Study of the MyoRegulator® device for treatment of ALS (NCT06165172), the CALM study will further assess the feasibility of the MyoRegulator® device to treat ALS in an expanded number of individuals with ALS. CALM will gather additional preliminary e...

What is the current status of trial NCT06649955?

This trial is currently recruiting. It is a NA study. The enrollment target is 15 participants. The study started on 2025-02-10. Estimated completion is 2026-11.

What conditions does trial NCT06649955 study?

This clinical trial studies the following conditions: ALS (Amyotrophic Lateral Sclerosis).

What interventions are being tested in trial NCT06649955?

The interventions under investigation include: Multi-site direct current stimulation (DCS) (DEVICE).

Who is sponsoring clinical trial NCT06649955?

This trial is sponsored by PathMaker Neurosystems, which has 3 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06649955 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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