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NCT06648629 · ClinicalTrials.gov registry record · NA
Acceptance and Commitment Therapy for HIV+ Hazardous Drinkers
A NA study of Alcohol Drinking and HIV-1-infection, sponsored by Syracuse University.
- Recruiting
- Registry status
- NA
- Development phase
- 300
- Enrollment target
- 1
- Study location
NCT06648629: Recruiting NA study of Alcohol Drinking and HIV-1-infection, sponsored by Syracuse University.
NCT06648629 is a NA study of Alcohol Drinking and HIV-1-infection that is actively recruiting participants, run by Syracuse University. The registered enrollment target is 300 participants, below the 627-participant average among 85 other Alcohol Drinking trials with a reported enrollment target (52% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06648629, a NA study of Alcohol Drinking and HIV-1-infection, is actively recruiting participants, sponsored by Syracuse University.
- RECRUITING
- Registry status
- NA
- Development phase
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
Alcohol consumption is a critical factor in HIV treatment that significantly contributes to poor treatment-related outcomes. Randomized clinical trials (RCTs) of alcohol interventions for people with HIV (PWH) have had limited success, perhaps due to an increasingly recognized co-morbitity of co-occurring hazardous alcohol use and other mental health-related problems among PWH. This has necessitated a shift in the literature towards trans-diagnostic approaches that target core psychological processes that underlie multiple mental health-related problems. One trans-diagnostic mechanism that is relevant to alcohol and other substance use is experiential avoidance (EA)- i.e., repeated, and maladaptive, use of substances and/or other behaviors to escape or avoid unwanted thoughts, feelings, and/or urges. Acceptance and commitment therapy (ACT) targets EA and is an empirically supported treatment for multiple psychological and behavioral health-related outcomes; however there have not been any full-scale RCTs of ACT for alcohol use among any population, including PWH. The investigators recently adapted a telephone-delivered ACT intervention originally developed for smoking cessation, into an intervention for PWH who drink at unhealthy levels (NIH/NIAAA; R34AA026246). This six-session, telephone-delivered ACT intervention for alcohol use showed high feasibility and acceptability in a pilot RCT conducted by our team. The overall objective of this application is therefore to determine if ACT can significantly reduce alcohol use and comorbid symptoms of depression, anxiety, and stress among adult PWH who drink at unhealthy levels. The specific aims are: To determine the relative efficacy of ACT, compared to BI, for reducing alcohol use among PWH (Aim 1) and to determine if ACT has an effect on trans-diagnostic processes that in turn affect alcohol use and other psychological and functional outcomes (Aim 2). The investigators will accomplish these aims by: conducting a remote
Primary Outcome
The Timeline Followback will be used to estimate the Number of Drinking Days 30 days prior to study visit appointment
Conditions Studied
Interventions
- BEHAVIORAL Acceptance and Commitment Therapy (ACT)
- BEHAVIORAL Brief Alcohol Intervention
Study Locations (1)
New York
- Syracuse University - Syracuse
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2025-01-22 |
| Est. Completion | 2028-08 |
| Phase | NA |
What NCT06648629 shows while recruiting
NCT06648629 is an interventional study that assigns participants to a tested intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, below the 627-participant average among 85 other Alcohol Drinking trials with a reported enrollment target (52% lower).
The record links to 2 conditions, with Alcohol Drinking appearing as the primary indexed condition, and to 2 interventions - of which Acceptance and Commitment Therapy (ACT) is the first listed.
NCT06648629 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT06648629 about?
NCT06648629 is a clinical study titled "Acceptance and Commitment Therapy for HIV+ Hazardous Drinkers". Alcohol consumption is a critical factor in HIV treatment that significantly contributes to poor treatment-related outcomes. Randomized clinical trials (RCTs) of alcohol interventions for people with HIV (PWH) have had limited success, perhaps due to an increasingly recognized co-morbitity of co-occ...
What is the current status of trial NCT06648629?
This trial is currently recruiting. It is a NA study. The enrollment target is 300 participants. The study started on 2025-01-22. Estimated completion is 2028-08.
What conditions does trial NCT06648629 study?
This clinical trial studies the following conditions: Alcohol Drinking, HIV-1-infection.
What interventions are being tested in trial NCT06648629?
The interventions under investigation include: Acceptance and Commitment Therapy (ACT) (BEHAVIORAL), Brief Alcohol Intervention (BEHAVIORAL).
Who is sponsoring clinical trial NCT06648629?
This trial is sponsored by Syracuse University, which has 31 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06648629 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Drinking
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06648629's enrollment target sits among peer trials
300 33rd of 85 higher than 52 of 85 other Alcohol Drinking trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Drinking trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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