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NCT06625398 · ClinicalTrials.gov registry record · Phase 3
An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants With Chronic Thyroid Eye Disease (TED)
A Phase 3 study of Thyroid Eye Disease, sponsored by Viridian Therapeutics.
- Active
- Registry status
- Phase 3
- Development phase
- 195
- Enrollment target
- 20
- Study locations
NCT06625398: Active Phase 3 study of Thyroid Eye Disease, sponsored by Viridian Therapeutics.
NCT06625398 is a Phase 3 study of Thyroid Eye Disease that is active but no longer recruiting, run by Viridian Therapeutics. The registered enrollment target is 195 participants, above the 93-participant average among 15 other Thyroid Eye Disease trials with a reported enrollment target (110% higher). The trial reports 20 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06625398, a Phase 3 study of Thyroid Eye Disease, is active but no longer recruiting, sponsored by Viridian Therapeutics.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 195 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a clinical trial assessing the efficacy, safety, and tolerability of an investigational drug, VRDN-003, in participants with chronic Thyroid Eye Disease (TED).
Primary Outcome
Description: Proportion of participants with a ≥2 mm reduction from baseline in proptosis in the most proptotic eye as measured by exophtalmometer \[without a corresponding increase of ≥2 mm in the other eye\]
Conditions Studied
Interventions
- DRUG Placebo
- DRUG VRDN-003
Study Locations (20)
California
- Alliance Research Institute - Canoga Park - Canoga Park
- Marvel Clinical Research - Huntington Beach
- United Medical Research Institute - Inglewood
- Advancing Research International, LLC - Los Angeles
- Roski Eye Institute, Keck School of Medicine, USC - Los Angeles
- Alliance Research Institute - Lynwood - Lynwood
- A.P.J. Office - Newport Beach
- Byers Eye Institute at Stanford University - Palo Alto
- Pasadena Clinical Trials - Pasadena
- Senta Clinic - San Diego
Florida
- Ilumina Medical Research - Kissimmee
- Med-Care Research - Miami
- Hype Clinical Research LLC - Miami
- Anmed Health Services LLC - Miami
- Southern Clinical Research LLc - Miami
- Sarasota Retina Institute - Sarasota
Arizona
- Scottsdale Clinical Trials - Scottsdale
Georgia
- Agile Clinical Research Trials, LLC - Atlanta
Illinois
- Vision Medical Research - Orland Park
Massachusetts
- Massachusetts Eye and Ear - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 195 participants |
| Start Date | 2024-08-27 |
| Est. Completion | 2026-12-15 |
| Phase | Phase 3 |
What the registry record for NCT06625398 still lists
NCT06625398 is an interventional study that assigns participants to a tested intervention. The registered 195 participants enrollment target is mid-sized for trials with a published cap, above the 93-participant average among 15 other Thyroid Eye Disease trials with a reported enrollment target (110% higher).
The record links to 1 condition, with Thyroid Eye Disease appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06625398 names 20 study sites across 6 states, led by California, Florida, Arizona.
Frequently Asked Questions
What is clinical trial NCT06625398 about?
NCT06625398 is a clinical study titled "An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants With Chronic Thyroid Eye Disease (TED)". This is a clinical trial assessing the efficacy, safety, and tolerability of an investigational drug, VRDN-003, in participants with chronic Thyroid Eye Disease (TED).
What is the current status of trial NCT06625398?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 195 participants. The study started on 2024-08-27. Estimated completion is 2026-12-15.
What conditions does trial NCT06625398 study?
This clinical trial studies the following conditions: Thyroid Eye Disease.
What interventions are being tested in trial NCT06625398?
The interventions under investigation include: Placebo (DRUG), VRDN-003 (DRUG).
Who is sponsoring clinical trial NCT06625398?
This trial is sponsored by Viridian Therapeutics, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06625398 being conducted?
This trial has 20 study locations across Arizona, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Thyroid Eye Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06625398's enrollment target sits among peer trials
195 1st of 15 higher than 15 of 15 other Thyroid Eye Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Thyroid Eye Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants With Active Thyroid Eye Disease (TED)
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A Safety, Tolerability and Pharmacokinetics Study of VRDN-003 in Participants With Thyroid Eye Disease (TED)
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A Trial to Investigate Teprotumumab Subcutaneous Administration Compared With Placebo in Male and Female Adult Participants With Moderate-to-severe Active Thyroid Eye Disease
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