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RECRUITING Phase 3

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

NCT06612268 · View on ClinicalTrials.gov ↗

Study Summary

This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle cell disease. The study will also evaluate how well etavopivat can reduce the damage to different organs, improve your exercise tolerance and reduce fatigue in people with sickle cell disease.The participants will either get etavopivat or placebo. Which treatment the participants will get is decided by chance. Etavopivat is a new medicine and is currently being tested in other studies in addition to this one. The study will last for about 2 years.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Etavopivat

Study Locations (20)

California

  • Children's Hospital Los Angeles - Endocrinology — Los Angeles
  • UCLA Health — Los Angeles
  • Valley Children's Hospital — Madera
  • University Of California Irvine — Orange
  • Stanford University_Palo Alto — Palo Alto
  • Harbor-UCLA Medical Center — Torrance

Alabama

  • Uni of Alabama at Birmingham — Birmingham
  • Univer South Alabama Ped/Onc — Mobile

District of Columbia

  • Childrens National Medical Ctr — Washington D.C.
  • MedStar Hlth Res Institute — Washington D.C.

Illinois

  • Childrens Hospital of Chicago — Chicago
  • Univer Of Illinois at Chicago — Chicago

Arizona

  • Phoenix Children's Hsptl — Phoenix

Arkansas

  • Arkansas Children's Hospital — Little Rock

Colorado

  • Clinical and Transl Res Center — Aurora

Delaware

  • Nemours/AI duPont Hosp-Chld — Wilmington

Trial Details

FieldValue
Enrollment Target 408 participants
Start Date 2025-02-17
Est. Completion 2029-03-12
Phase Phase 3

Sponsor

Novo Nordisk A/S

189 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06612268

The ClinicalTrials.gov registry entry for NCT06612268 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 408 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novo Nordisk A/S, which has 189 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Sickle Cell Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06612268 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Alabama, District of Columbia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06612268 about?

NCT06612268 is a clinical study titled "A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease". This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle cell disease. The study will also evaluate how well etavopivat can redu...

What is the current status of trial NCT06612268?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 408 participants. The study started on 2025-02-17. Estimated completion is 2029-03-12.

What conditions does trial NCT06612268 study?

This clinical trial studies the following conditions: Sickle Cell Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06612268?

The interventions under investigation include: Placebo (DRUG), Etavopivat (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06612268?

This trial is sponsored by Novo Nordisk A/S, which has 189 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06612268 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial