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RECRUITING Phase 3

A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

NCT06609226 · View on ClinicalTrials.gov ↗

Study Summary

Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are inherited blood disorders that affect haemoglobin. Haemoglobin is the protein that carries oxygen through the body. This study is looking into how safe treatment with etavopivat is and how well it works over a long period of time. The study will last for up to 264 weeks, but it will end earlier if etavopivat is approved in the participant's country.

Interventions

  • DRUG Etavopivat A
  • DRUG Etavopivat B
  • DRUG Etavopivat C

Study Locations (20)

California

  • Children's Hospital Los Angeles - Endocrinology — Los Angeles
  • Children's Hospital Los Angeles - Endocrinology — Los Angeles
  • UCSF Oakland Benioff ChildHosp — Oakland
  • UCSF Oakland Benioff ChildHosp — Oakland
  • Children's Hosp Of Orange — Orange
  • University Of California Irvine — Orange

Georgia

  • Emory University School of Medicine — Atlanta
  • Children's Healthcare Atlanta — Atlanta
  • Center for Blood Disorders Augusta University — Augusta

Florida

  • Foundation for Sickle Cell Disease Research — Hollywood
  • Univ of Miami/SCCC — Miami

Alabama

  • Univ of Alabama Birmingham — Birmingham

Arizona

  • Phoenix Children's Hsptl — Phoenix

Connecticut

  • University of Connecticut — Farmington

District of Columbia

  • Children's National Medical Center — Washington D.C.

Illinois

  • Univer Of Illinois at Chicago — Chicago

Trial Details

FieldValue
Enrollment Target 480 participants
Start Date 2025-01-10
Est. Completion 2030-12-30
Phase Phase 3

Sponsor

Novo Nordisk A/S

189 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06609226

The ClinicalTrials.gov registry entry for NCT06609226 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 480 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novo Nordisk A/S, which has 189 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Sickle Cell Disease appearing as the primary indexed condition, and to 3 interventions — of which Etavopivat A is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06609226 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Georgia, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06609226 about?

NCT06609226 is a clinical study titled "A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia". Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are inherited blood disorders that affect haemoglobin. Haemoglobin is the protein that carries oxygen through the body. This study is looking in...

What is the current status of trial NCT06609226?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 480 participants. The study started on 2025-01-10. Estimated completion is 2030-12-30.

What conditions does trial NCT06609226 study?

This clinical trial studies the following conditions: Sickle Cell Disease, Thalassemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06609226?

The interventions under investigation include: Etavopivat A (DRUG), Etavopivat B (DRUG), Etavopivat C (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06609226?

This trial is sponsored by Novo Nordisk A/S, which has 189 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06609226 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Connecticut, District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial