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NCT06540976 · ClinicalTrials.gov registry record · NA
Posterior Cingulate Cortex and Executive Control of Episodic Memory
A NA study of Episodic Memory, sponsored by University of Pennsylvania.
- Recruiting
- Registry status
- NA
- Development phase
- 130
- Enrollment target
- 1
- Study location
NCT06540976: Recruiting NA study of Episodic Memory, sponsored by University of Pennsylvania.
NCT06540976 is a NA study of Episodic Memory that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 130 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06540976, a NA study of Episodic Memory, is actively recruiting participants, sponsored by University of Pennsylvania.
- RECRUITING
- Registry status
- NA
- Development phase
- 130 participants
- Enrollment target
- 1
- Study location
Study Summary
This project will use intracranial recordings and stimulation of the human brain to understand the unique contributions of the posterior cingulate cortex (PCC) to episodic memory behavior. The goal is to test how distinct subregions of the PCC differentially contribute to memory-based decisions (e.g., have I seen this picture before?). The ability to perform invasive studies of the human brain is through routine clinical monitoring of brain activity which occurs during the neurosurgical treatment of epilepsy. However, this project only focuses on the basic science of PCC and memory behavior. Specifically, the investigators will use single-0cell and population measures of brain activity to test a new theory of PCC function which focuses on the executive processes needed to support memory retrieval and memory-based decisions. By studying the PCC, a convergence zone of memory and executive brain systems, progress can be made in elucidating how the failure to successfully leverage past experiences in daily behavior can occur as a common symptom of both neurodegenerative disease (e.g., Alzheimer's disease) and multiple psychiatric conditions (e.g., schizophrenia) implicating PCC dysfunction.
Primary Outcome
Participants will perform three tasks each testing the accuracy of executive (reward) or episodic (memory strength) based decisions. Outcome measures will be decision accuracy (% correct).
Conditions Studied
Interventions
- BEHAVIORAL Cognitive testing
Study Locations (1)
Pennsylvania
- Hospital of the University of Pennsylvania - Pavilion - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 130 participants |
| Start Date | 2023-01-18 |
| Est. Completion | 2027-04-30 |
| Phase | NA |
What NCT06540976 shows while recruiting
NCT06540976 is an interventional study that assigns participants to a tested intervention. The registered 130 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (91% lower).
The record links to 1 condition, with Episodic Memory appearing as the primary indexed condition, and to 1 intervention - of which Cognitive testing is the first listed.
NCT06540976 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06540976 about?
NCT06540976 is a clinical study titled "Posterior Cingulate Cortex and Executive Control of Episodic Memory". This project will use intracranial recordings and stimulation of the human brain to understand the unique contributions of the posterior cingulate cortex (PCC) to episodic memory behavior. The goal is to test how distinct subregions of the PCC differentially contribute to memory-based decisions (e.g...
What is the current status of trial NCT06540976?
This trial is currently recruiting. It is a NA study. The enrollment target is 130 participants. The study started on 2023-01-18. Estimated completion is 2027-04-30.
What conditions does trial NCT06540976 study?
This clinical trial studies the following conditions: Episodic Memory.
What interventions are being tested in trial NCT06540976?
The interventions under investigation include: Cognitive testing (BEHAVIORAL).
Who is sponsoring clinical trial NCT06540976?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06540976 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Episodic Memory
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06540976's enrollment target sits among peer trials
130 733rd of 2000 higher than 1,258 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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