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NCT06491732 · ClinicalTrials.gov registry record
EIM Via the Myolex mScan as an ALS Biomarker
A clinical trial of Amyotrophic Lateral Sclerosis, sponsored by Beth Israel Deaconess Medical Center.
- Recruiting
- Registry status
- 80
- Enrollment target
- 1
- Study location
NCT06491732: Recruiting study of Amyotrophic Lateral Sclerosis, sponsored by Beth Israel Deaconess Medical Center.
NCT06491732 is a study of Amyotrophic Lateral Sclerosis that is actively recruiting participants, run by Beth Israel Deaconess Medical Center. The registered enrollment target is 80 participants, below the 897-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06491732, a study of Amyotrophic Lateral Sclerosis, is actively recruiting participants, sponsored by Beth Israel Deaconess Medical Center.
- RECRUITING
- Registry status
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
Amyotrophic lateral sclerosis (ALS) has been traditionally considered incurable and untreatable. But starting in the 1990s with the introduction of Riluzole, therapies are being discovered and ultimately approved for slowing disease progression. Many pharmaceutical companies continue to seek new therapeutic approaches. One critical aspect of all clinical trials is the need track to progression sensitively to identify the impact of therapy. Tools to track ALS progression must be convenient, objective, require minimal training, be easily standardized, cost-efficient, and have the potential to be applied effectively at home. There has been a push to identify accurate, objective biomarkers of ALS progression. In this study, the investigators propose to use Electrical impedance myography (EIM) to evaluate the progression of the disease. Work has shown that the EIM 50 kilohertz (kHz) phase value from one or more muscles, followed sequentially, can serve as an effective overall biomarker for assessing the rate of ALS progression for a single person.
Primary Outcome
Mean and standard deviation in rate of change in EIM phase values compared to mean and standard deviation in rate of change in ALSFRS-R over 8 months
Conditions Studied
Interventions
- DEVICE Electrical Impedance Myography
Study Locations (1)
Massachusetts
- Beth Israel Deaconess Medical Center - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2025-03-01 |
| Est. Completion | 2026-09-30 |
What NCT06491732 shows while recruiting
NCT06491732 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 897-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (91% lower).
The record links to 1 condition, with Amyotrophic Lateral Sclerosis appearing as the primary indexed condition, and to 1 intervention - of which Electrical Impedance Myography is the first listed.
NCT06491732 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06491732 about?
NCT06491732 is a clinical study titled "EIM Via the Myolex mScan as an ALS Biomarker". Amyotrophic lateral sclerosis (ALS) has been traditionally considered incurable and untreatable. But starting in the 1990s with the introduction of Riluzole, therapies are being discovered and ultimately approved for slowing disease progression. Many pharmaceutical companies continue to seek new the...
What is the current status of trial NCT06491732?
This trial is currently recruiting. The enrollment target is 80 participants. The study started on 2025-03-01. Estimated completion is 2026-09-30.
What conditions does trial NCT06491732 study?
This clinical trial studies the following conditions: Amyotrophic Lateral Sclerosis.
What interventions are being tested in trial NCT06491732?
The interventions under investigation include: Electrical Impedance Myography (DEVICE).
Who is sponsoring clinical trial NCT06491732?
This trial is sponsored by Beth Israel Deaconess Medical Center, which has 488 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06491732 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06491732's enrollment target sits among peer trials
80 46th of 102 higher than 57 of 102 other Amyotrophic Lateral Sclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Amyotrophic Lateral Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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