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NCT06476847 · ClinicalTrials.gov registry record · NA
A Simple Intervention to Increase Persistence on PrEP in MSM to Improve Decision Making
A NA study of HIV Infections, sponsored by Boston University.
- Active
- Registry status
- NA
- Development phase
- 106
- Enrollment target
- 2
- Study locations
NCT06476847: Active NA study of HIV Infections, sponsored by Boston University.
NCT06476847 is a NA study of HIV Infections that is active but no longer recruiting, run by Boston University. The registered enrollment target is 106 participants, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (76% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06476847, a NA study of HIV Infections, is active but no longer recruiting, sponsored by Boston University.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 106 participants
- Enrollment target
- 2
- Study locations
Study Summary
Oral HIV pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention modality that requires individuals to take a daily tablet to prevent themselves acquiring HIV. In South Africa while this is freely available in the public sector, persistence (that is continuation after initiation) is low amongst vulnerable populations, including men who have sex with men (MSM). This study is a feasibility and acceptability study of a behavioral economics informed intervention to improve persistence amongst MSM newly initiating PrEP in South Africa. The goal of this study is to show that this approach is possible in a routine setting and gather the necessary data for a fully powered effectiveness trial. Study participants will complete a baseline questionnaire and then be randomized to either receive standard of care (control) or to receive the intervention. The intervention package consists of evidence informed reminders, commitment pledges and planning prompts. The intervention package aims to address present bias, optimism bias and salience. The intervention is delivered and the enrollment visit and then through mobile phone reminders / text messages. There is no further in person interaction after the initial interaction. Participants may be contacted for a telephonic enplane questionnaire. Outcome data is obtained from passive followup through routine medical record review with the primary end point being persistence at 3 months.
Primary Outcome
The percent of participants enrolled from those that meet eligibility criteria and are offered will be assessed from screening log.
Conditions Studied
Interventions
- BEHAVIORAL PrEP persistence
Study Locations (2)
Massachusetts
- Boston Univeristy School ofPublic Health, Global Health - Boston
Gauteng
- The Aurum POP INN Clinic - Pretoria
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 106 participants |
| Start Date | 2025-01-23 |
| Est. Completion | 2026-09 |
| Phase | NA |
What the registry record for NCT06476847 still lists
NCT06476847 is an interventional study that assigns participants to a tested intervention. The registered 106 participants enrollment target is mid-sized for trials with a published cap, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (76% lower).
The record links to 1 condition, with HIV Infections appearing as the primary indexed condition, and to 1 intervention - of which PrEP persistence is the first listed.
NCT06476847 reports a single indexed study location in Massachusetts, Gauteng.
Frequently Asked Questions
What is clinical trial NCT06476847 about?
NCT06476847 is a clinical study titled "A Simple Intervention to Increase Persistence on PrEP in MSM to Improve Decision Making". Oral HIV pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention modality that requires individuals to take a daily tablet to prevent themselves acquiring HIV. In South Africa while this is freely available in the public sector, persistence (that is continuation after initiation) is low...
What is the current status of trial NCT06476847?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 106 participants. The study started on 2025-01-23. Estimated completion is 2026-09.
What conditions does trial NCT06476847 study?
This clinical trial studies the following conditions: HIV Infections.
What interventions are being tested in trial NCT06476847?
The interventions under investigation include: PrEP persistence (BEHAVIORAL).
Who is sponsoring clinical trial NCT06476847?
This trial is sponsored by Boston University, which has 185 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06476847 being conducted?
This trial has 2 study locations across Massachusetts, Gauteng. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for HIV Infections
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06476847's enrollment target sits among peer trials
106 257th of 542 higher than 285 of 542 other HIV Infections trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other HIV Infections trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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