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NCT06475807 · ClinicalTrials.gov registry record · NA
Dietary Interventions in Cancer Patients Treated With Immune Checkpoint Inhibitors
A NA study of Cancer, sponsored by University of Pittsburgh.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06475807: Recruiting NA study of Cancer, sponsored by University of Pittsburgh.
NCT06475807 is a NA study of Cancer that is actively recruiting participants, run by University of Pittsburgh. The registered enrollment target is 60 participants, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06475807, a NA study of Cancer, is actively recruiting participants, sponsored by University of Pittsburgh.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
This pilot trial will study the potential impact of two distinct dietary interventions with sequential use of high-fermented foods and high-fiber supplements on the gut microbiome and antitumor immunity in patients with melanoma and non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors. The trial aims to understand how dietary changes affect the composition and function of the gut microbiome, together with immunological and metabolomic markers in serum in patients with melanoma and NSCLC who are undergoing standard-of-care treatment with a PD-1/PD-L1 Inhibitors (neoadjuvant, adjuvant or consolidation)
Primary Outcome
Changes in gut microbiome diversity and function, evaluated with metagenomics, identify differentially abundant taxa and assess all genes in all organisms present in each fecal microbiota sample in pre- vs. post- each dietary using PERMANOVA. This will be measured as change of cell frequency and calculated as percentage change.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT High-fermented food
- DIETARY_SUPPLEMENT High fiber supplementation
Study Locations (1)
Pennsylvania
- UPMC Hillman Cancer Center - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-07-17 |
| Est. Completion | 2027-06 |
| Phase | NA |
What NCT06475807 shows while recruiting
NCT06475807 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Cancer appearing as the primary indexed condition, and to 2 interventions - of which High-fermented food is the first listed.
NCT06475807 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06475807 about?
NCT06475807 is a clinical study titled "Dietary Interventions in Cancer Patients Treated With Immune Checkpoint Inhibitors". This pilot trial will study the potential impact of two distinct dietary interventions with sequential use of high-fermented foods and high-fiber supplements on the gut microbiome and antitumor immunity in patients with melanoma and non-small cell lung cancer (NSCLC) treated with immune checkpoint i...
What is the current status of trial NCT06475807?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2024-07-17. Estimated completion is 2027-06.
What conditions does trial NCT06475807 study?
This clinical trial studies the following conditions: Cancer.
What interventions are being tested in trial NCT06475807?
The interventions under investigation include: High-fermented food (DIETARY_SUPPLEMENT), High fiber supplementation (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT06475807?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06475807 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06475807's enrollment target sits among peer trials
60 393rd of 615 higher than 208 of 615 other Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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