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NCT06366230 · ClinicalTrials.gov registry record · Phase 1
Adding Urea to the Final Dialysis Fluid
A Phase 1 study of ESRD and Hyperkalemia, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT06366230 is a Phase 1 study of ESRD and Hyperkalemia that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 20 participants, below the 139-participant average among 13 other ESRD trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06366230, a Phase 1 study of ESRD and Hyperkalemia, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
At times patients with advanced renal failure present with severe hyperkalemia or acidosis and very high serum blood urea nitrogen (BUN) concentrations. These patients cannot be dialyzed aggressively as the lowering of serum BUN may results in disequilibrium syndrome but on the other hand they need aggressive dialysis in order to lower their serum potassium or fix their severe acidosis. If one is able to add urea to the dialysis fluid, one can prevent the rapid lowering of serum BUN and osmolality at the same time as doing aggressive dialysis to lower serum potassium and/or fix the metabolic acidosis.
Conditions Studied
Interventions
- DRUG Urea in the dialysate
Study Locations (1)
California
- Zuckerberg San Francisco General Hospital - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-09-16 |
| Est. Completion | 2028-06-30 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06366230
The ClinicalTrials.gov registry entry for NCT06366230 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 139-participant average among 13 other ESRD trials with a reported enrollment target (86% lower). The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with ESRD appearing as the primary indexed condition, and to 1 intervention - of which Urea in the dialysate is the first listed.
NCT06366230 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT06366230 about?
NCT06366230 is a clinical study titled "Adding Urea to the Final Dialysis Fluid". At times patients with advanced renal failure present with severe hyperkalemia or acidosis and very high serum blood urea nitrogen (BUN) concentrations. These patients cannot be dialyzed aggressively as the lowering of serum BUN may results in disequilibrium syndrome but on the other hand they need ...
What is the current status of trial NCT06366230?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2025-09-16. Estimated completion is 2028-06-30.
What conditions does trial NCT06366230 study?
This clinical trial studies the following conditions: ESRD, Hyperkalemia, Metabolic Acidosis, Dysequilibrium Syndrome.
What interventions are being tested in trial NCT06366230?
The interventions under investigation include: Urea in the dialysate (DRUG).
Who is sponsoring clinical trial NCT06366230?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06366230 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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