Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 3

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

NCT06292013 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin). Approximately 1700 additional participants will be enrolled in an addendum to explore Lp(a) lowering with an alternative dosing schema.

Interventions

  • DRUG Placebo
  • DRUG Lepodisiran Sodium

Study Locations (20)

Arizona

  • Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC — Gilbert
  • Mercy Gilbert Medical Center — Gilbert
  • Sun City Clinical Research — Glendale
  • Elite Clinical Studies, LLC — Phoenix
  • Helios Clinical Research - Phoenix — Phoenix
  • Absolute Clinical Research — Phoenix
  • Clinical Research Institute of Arizona (CRI) - Sun City West — Sun City West
  • Pima Heart — Tucson
  • Synexus Clinical Research US, Inc./Orange Grove Family Practice — Tucson
  • Eclipse Clinical Research — Tucson

Alabama

  • Birmingham Clinical Research — Birmingham
  • Alliance for Multispecialty Research, LLC — Daphne
  • SEC Clinical Research — Dothan
  • Alliance for Multispecialty Research, LLC — Mobile
  • Mobile Heart Specialists — Mobile

California

  • National Heart Institute — Beverly Hills
  • Valley Clinical Trials, Inc. — Covina
  • Neighborhood Healthcare Institute of Health — Escondido
  • HB Clinical Trials - Fountain Valley — Fountain Valley

Arkansas

  • Cardiology and Medicine Clinic — Little Rock

Trial Details

FieldValue
Enrollment Target 17,300 participants
Start Date 2024-03-05
Est. Completion 2029-03
Phase Phase 3

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06292013

The ClinicalTrials.gov registry entry for NCT06292013 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 17,300 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Atherosclerotic Cardiovascular Disease (ASCVD) appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06292013 reports 20 study locations spanning 4 distinct geographic areas — top geographies include Arizona, Alabama, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06292013 about?

NCT06292013 is a clinical study titled "A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)". The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin). Approxim...

What is the current status of trial NCT06292013?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 17,300 participants. The study started on 2024-03-05. Estimated completion is 2029-03.

What conditions does trial NCT06292013 study?

This clinical trial studies the following conditions: Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06292013?

The interventions under investigation include: Placebo (DRUG), Lepodisiran Sodium (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06292013?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06292013 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial