Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 3

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

NCT06383390 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m\^2 or higher and Atherosclerotic Cardiovascular Disease and/or chronic kidney disease. The study will last for about 5 years. Participants will have up to 27 clinic visits with the study doctor.

Interventions

  • DRUG Placebo
  • DRUG Retatrutide

Study Locations (20)

Arizona

  • Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC — Gilbert
  • Sun City Clinical Research — Glendale
  • Arizona Kidney Disease & Hypertension Center (AKDHC) - Thunderbird — Glendale
  • Helios Clinical Research - SAZ-PDV-026 — Paradise Valley
  • Banner University Medical Center Phoenix — Phoenix
  • Phoenix Clinical LLC — Phoenix
  • Elite Clinical Studies, LLC — Phoenix
  • Absolute Clinical Research — Phoenix
  • Scottsdale Clinical Trials — Scottsdale
  • Clinical Research Institute of Arizona (CRI) - Sun City West — Sun City West
  • Synexus Clinical Research US, Inc./Orange Grove Family Practice — Tucson

Alabama

  • Alabama Kidney Research — Alabaster
  • Central Research Associates — Birmingham
  • Alliance for Multispecialty Research, LLC — Daphne
  • Nephrology Consultants — Huntsville
  • Alliance for Multispecialty Research, LLC — Mobile

California

  • Kidney & Hypertension Center - Apple Valley — Apple Valley
  • Invivo - Bakersfield — Bakersfield
  • American Institute of Research — Beverly Hills

Arkansas

  • Cardiology and Medicine Clinic — Little Rock

Trial Details

FieldValue
Enrollment Target 10,000 participants
Start Date 2024-04-30
Est. Completion 2029-02
Phase Phase 3

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06383390

The ClinicalTrials.gov registry entry for NCT06383390 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 10,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Chronic Kidney Disease (CKD) appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06383390 reports 20 study locations spanning 4 distinct geographic areas — top geographies include Arizona, Alabama, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06383390 about?

NCT06383390 is a clinical study titled "The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)". The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m\^2 or higher and Atherosclerotic Cardiovascular Disease an...

What is the current status of trial NCT06383390?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 10,000 participants. The study started on 2024-04-30. Estimated completion is 2029-02.

What conditions does trial NCT06383390 study?

This clinical trial studies the following conditions: Chronic Kidney Disease (CKD), Atherosclerotic Cardiovascular Disease (ASCVD). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06383390?

The interventions under investigation include: Placebo (DRUG), Retatrutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06383390?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06383390 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial