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NCT06282406 · ClinicalTrials.gov registry record · NA
Pupil-Indexed Noninvasive Neuromodulation
A NA study of Paresis, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- NA
- Development phase
- 110
- Enrollment target
- 1
- Study location
NCT06282406: Recruiting NA study of Paresis, sponsored by VA Office of Research and Development.
NCT06282406 is a NA study of Paresis that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 110 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06282406, a NA study of Paresis, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- NA
- Development phase
- 110 participants
- Enrollment target
- 1
- Study location
Study Summary
Vagus nerve stimulation (VNS) is thought to activate neural pathways that release chemicals which promote plasticity and learning. Previous work has shown that the auricular branch of the vagus nerve innervates landmarks on the external ear. Work from the PI's laboratory has shown that electrical current applied to the external ear modulates physiological indexes of brain states implicated in the therapeutic effects of VNS. The broad objective of this project is to better understand physiological mechanisms modulated by auricular stimulation to support possible therapeutic effects in the form of motor learning.
Primary Outcome
Subjects will be tested on the same task used for training that involves controlling finger forces.
Conditions Studied
Interventions
- OTHER Sham
- OTHER Transcutaneous Electrical Stimulation
Study Locations (1)
Pennsylvania
- VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 110 participants |
| Start Date | 2024-06-03 |
| Est. Completion | 2028-08-05 |
| Phase | NA |
What NCT06282406 shows while recruiting
NCT06282406 is an interventional study that assigns participants to a tested intervention. The registered 110 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Paresis appearing as the primary indexed condition, and to 2 interventions - of which Sham is the first listed.
NCT06282406 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06282406 about?
NCT06282406 is a clinical study titled "Pupil-Indexed Noninvasive Neuromodulation". Vagus nerve stimulation (VNS) is thought to activate neural pathways that release chemicals which promote plasticity and learning. Previous work has shown that the auricular branch of the vagus nerve innervates landmarks on the external ear. Work from the PI's laboratory has shown that electrical cu...
What is the current status of trial NCT06282406?
This trial is currently recruiting. It is a NA study. The enrollment target is 110 participants. The study started on 2024-06-03. Estimated completion is 2028-08-05.
What conditions does trial NCT06282406 study?
This clinical trial studies the following conditions: Paresis.
What interventions are being tested in trial NCT06282406?
The interventions under investigation include: Sham (OTHER), Transcutaneous Electrical Stimulation (OTHER).
Who is sponsoring clinical trial NCT06282406?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06282406 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Paresis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06282406's enrollment target sits among peer trials
110 816th of 2000 higher than 1,176 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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