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NCT06246396 · ClinicalTrials.gov registry record · Phase 4
Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
A Phase 4 study of Hypertension, Resistant to Conventional Therapy, sponsored by University of Florida.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT06246396: Recruiting Phase 4 study of Hypertension, Resistant to Conventional Therapy, sponsored by University of Florida.
NCT06246396 is a Phase 4 study of Hypertension, Resistant to Conventional Therapy that is actively recruiting participants, run by University of Florida. The registered enrollment target is 120 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (77% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06246396, a Phase 4 study of Hypertension, Resistant to Conventional Therapy, is actively recruiting participants, sponsored by University of Florida.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension. The main questions it aims to answer are: * To what extent does minocycline lower blood pressure? * Are such blood pressure effects mediated through changes in gut microbiota, gut leakiness, systemic inflammation, neuroinflammation, or some combination of these? Participants will be randomly assigned to treatment with minocycline or placebo, treated daily for 3 months, to evaluate these questions.
Primary Outcome
Change in mean 24-hour ambulatory systolic blood pressure
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Minocycline Hydrochloride
Study Locations (1)
Florida
- UF Clinical Research Center (UF CRC) - CTSI - Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2025-01-08 |
| Est. Completion | 2028-07 |
| Phase | Phase 4 |
What NCT06246396 shows while recruiting
NCT06246396 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (77% lower).
The record links to 1 condition, with Hypertension, Resistant to Conventional Therapy appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06246396 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT06246396 about?
NCT06246396 is a clinical study titled "Antihypertensive Mechanisms of Minocycline in Resistant Hypertension". The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension. The main questions it aims to answer are: * To what extent does minocycline lower blood pressure? * Are such blood pressure effects media...
What is the current status of trial NCT06246396?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 120 participants. The study started on 2025-01-08. Estimated completion is 2028-07.
What conditions does trial NCT06246396 study?
This clinical trial studies the following conditions: Hypertension, Resistant to Conventional Therapy.
What interventions are being tested in trial NCT06246396?
The interventions under investigation include: Placebo (DRUG), Minocycline Hydrochloride (DRUG).
Who is sponsoring clinical trial NCT06246396?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06246396 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension, Resistant to Conventional Therapy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06246396's enrollment target sits among peer trials
120 673rd of 2000 higher than 1,290 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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