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NCT06228742 · ClinicalTrials.gov registry record · NA
Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle Disuse
A NA study, sponsored by United States Army Research Institute of Environmental Medicine.
- Completed
- Registry status
- NA
- Development phase
- 12
- Enrollment target
NCT06228742 is a NA study that has completed, run by United States Army Research Institute of Environmental Medicine. The registered enrollment target is 12 participants.
The verdict
NCT06228742, a NA study, has completed, sponsored by United States Army Research Institute of Environmental Medicine.
- COMPLETED
- Registry status
- NA
- Development phase
- 12 participants
- Enrollment target
Study Summary
This study will characterize intramuscular molecular mechanisms underlying anabolic resistance to protein ingestion during muscle disuse. Adults (n=12) will be studied using a unilateral leg immobilization model in which one leg will be randomly assigned to immobilization and the contralateral, active leg used as a within-subjects control. Immobilization will be implemented for five days using a rigid knee brace, during which time participants will ambulate using crutches. Integrated ribonucleic acid (RNA) synthesis will be determined during immobilization in the immobilized and non-immobilized legs using ingested deuterium oxide, salivary and blood sampling, and muscle biopsies. Immediately after immobilization, muscle biopsies will be collected before and 90 mins after consuming 25 g of whey protein from the immobilized and non-immobilized legs to characterize the intramuscular molecular response to protein feeding. Serial blood samples will be collected during that time to characterize the circulating metabolic response to protein ingestion. Knowledge generated from this effort will inform the development of targeted interventions for mitigating anabolic resistance to protein ingestion that develops during periods of muscle disuse.
Interventions
- OTHER Unilateral leg immobilization
- OTHER Contralateral active leg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2024-02-20 |
| Est. Completion | 2024-10-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06228742
The ClinicalTrials.gov registry entry for NCT06228742 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is United States Army Research Institute of Environmental Medicine, which has 59 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Unilateral leg immobilization is the first listed.
NCT06228742 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT06228742 about?
NCT06228742 is a clinical study titled "Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle Disuse". This study will characterize intramuscular molecular mechanisms underlying anabolic resistance to protein ingestion during muscle disuse. Adults (n=12) will be studied using a unilateral leg immobilization model in which one leg will be randomly assigned to immobilization and the contralateral, acti...
What is the current status of trial NCT06228742?
This trial is currently completed. It is a NA study. The enrollment target is 12 participants. The study started on 2024-02-20. Estimated completion is 2024-10-01.
What interventions are being tested in trial NCT06228742?
The interventions under investigation include: Unilateral leg immobilization (OTHER), Contralateral active leg (OTHER).
Who is sponsoring clinical trial NCT06228742?
This trial is sponsored by United States Army Research Institute of Environmental Medicine, which has 59 total clinical trials registered on ClinicalTrials.gov.
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