Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06228235 · ClinicalTrials.gov registry record · NA
rTMS-concurrent Behavioral Priming for Reducing Smoking Cravings
A NA study of Smoking Behaviors and Smoking Reduction, sponsored by West Virginia University.
- Recruiting
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT06228235 is a NA study of Smoking Behaviors and Smoking Reduction that is actively recruiting participants, run by West Virginia University. The registered enrollment target is 20 participants, below the 438-participant average among 21 other Smoking Behaviors trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06228235, a NA study of Smoking Behaviors and Smoking Reduction, is actively recruiting participants, sponsored by West Virginia University.
- RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The objective of this pilot clinical trial is to test the effects of different types of thinking strategies at the time of repetitive Transcranial Magnetic Stimulation (rTMS), applied to the left Dorsolateral Prefrontal Cortex (DLPFC), on smoking craving and brain activity. Participants will be individuals with moderate to high smoking dependence (smoking at least 8 cigarettes a day) who have no intention of quitting in the next 3 months and are eligible to have rTMS and functional magnetic resonance imaging (fMRI). The main objectives of the trial are: 1. To compare the craving-reducing effects of "upregulation" and "downregulation" of craving while looking at pictures related to cigarette smoking during rTMS versus no regulation of craving while looking at neutral pictures unrelated to smoking. 'Upregulation" is thinking about the immediate positive experience of smoking. "Downregulation" is thinking about the long-term negative consequences of smoking. 2. To examine changes in brain activity that accompany craving reductions produced by rTMS paired with upregulation and downregulation of craving while looking at pictures related to cigarette smoking versus no regulation of craving while looking at neutral pictures unrelated to smoking. Following screening for eligibility, participants will be trained on how to do upregulation and downregulation of craving. The participants will then participate in 3 testing sessions. In each session, the participants will receive rTMS at 20Hz in 50 trains (2000 pulses total), followed immediately by fMRI. Sessions will take place 1-2 weeks apart and will differ in the type of thinking strategy participants will use while looking at pictures during the rTMS: * upregulation of craving while viewing smoking-related images * downregulation of craving while viewing smoking-related images * no regulation of craving while viewing neutral smoking-unrelated images The order of sessions will be randomized across participants.
Conditions Studied
Interventions
- DEVICE Repetitive transcranial magnetic stimulation (rTMS)
Study Locations (1)
West Virginia
- West Virginia University - Morgantown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2024-04-16 |
| Est. Completion | 2026-05 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06228235
The ClinicalTrials.gov registry entry for NCT06228235 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 438-participant average among 21 other Smoking Behaviors trials with a reported enrollment target (95% lower). The listed sponsor is West Virginia University, which has 122 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Smoking Behaviors appearing as the primary indexed condition, and to 1 intervention - of which Repetitive transcranial magnetic stimulation (rTMS) is the first listed.
NCT06228235 reports 1 study location spanning 1 distinct geographic area - top geographies include West Virginia.
Frequently Asked Questions
What is clinical trial NCT06228235 about?
NCT06228235 is a clinical study titled "rTMS-concurrent Behavioral Priming for Reducing Smoking Cravings". The objective of this pilot clinical trial is to test the effects of different types of thinking strategies at the time of repetitive Transcranial Magnetic Stimulation (rTMS), applied to the left Dorsolateral Prefrontal Cortex (DLPFC), on smoking craving and brain activity. Participants will be indi...
What is the current status of trial NCT06228235?
This trial is currently recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2024-04-16. Estimated completion is 2026-05.
What conditions does trial NCT06228235 study?
This clinical trial studies the following conditions: Smoking Behaviors, Smoking Reduction.
What interventions are being tested in trial NCT06228235?
The interventions under investigation include: Repetitive transcranial magnetic stimulation (rTMS) (DEVICE).
Who is sponsoring clinical trial NCT06228235?
This trial is sponsored by West Virginia University, which has 122 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06228235 being conducted?
This trial has 1 study location across West Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Smoking Behaviors
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Influence of Authorized Smokeless Tobacco Product Modified Risk Claims I: Consumer Product Demand
RECRUITING · NA
-
ACT Lung Health Intervention: Phase Two
RECRUITING · NA
-
Smoke Free SafeCare: Establishing a Smoke Free Home in CPS-involved Families
RECRUITING · NA
-
Take A Break - Rural
RECRUITING · NA
-
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
RECRUITING · NA
-
A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
RECRUITING · NA
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.