Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06185686 · ClinicalTrials.gov registry record
Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients
A clinical trial of Brain Tumor, Primary, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- 16
- Enrollment target
- 1
- Study location
NCT06185686: Recruiting study of Brain Tumor, Primary, sponsored by Washington University School of Medicine.
NCT06185686 is a study of Brain Tumor, Primary that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 16 participants, below the 322-participant average among 3 other Brain Tumor, Primary trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06185686, a study of Brain Tumor, Primary, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- 16 participants
- Enrollment target
- 1
- Study location
Study Summary
With modern therapy, the survival rate for pediatric brain tumor patients has significantly improved, with over 70% of patients surviving their disease. However, this progress often comes at the cost of substantial morbidity, with cognitive deficits being the primary obstacle to independent living. Robust predictors of cognitive decline and a comprehensive understanding of the underlying mechanisms of cognitive injury remain elusive. This study will prospectively investigate alterations in brain resting state networks following radiation therapy using functional imaging. The hypothesis is that radiation therapy leads to dose-dependent alterations in functional connectivity in the networks associated with higher level cognition, ultimately leading to cognitive decline.
Primary Outcome
The investigators will compare resting state maps of each patient pre- and post-radiation therapy. The investigators will evaluate changes in the resting state architecture and compare to the average results that would be expected from a patient in the same age and sex.
Conditions Studied
Interventions
- OTHER Cognitive testing
- DEVICE Resting State MRI/Precision functional mapping
Study Locations (1)
Missouri
- Washington University School of Medicine/Saint Louis Children's Hospital - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2024-07-10 |
| Est. Completion | 2027-07-31 |
What NCT06185686 shows while recruiting
NCT06185686 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 322-participant average among 3 other Brain Tumor, Primary trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Brain Tumor, Primary appearing as the primary indexed condition, and to 2 interventions - of which Cognitive testing is the first listed.
NCT06185686 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT06185686 about?
NCT06185686 is a clinical study titled "Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients". With modern therapy, the survival rate for pediatric brain tumor patients has significantly improved, with over 70% of patients surviving their disease. However, this progress often comes at the cost of substantial morbidity, with cognitive deficits being the primary obstacle to independent living. ...
What is the current status of trial NCT06185686?
This trial is currently recruiting. The enrollment target is 16 participants. The study started on 2024-07-10. Estimated completion is 2027-07-31.
What conditions does trial NCT06185686 study?
This clinical trial studies the following conditions: Brain Tumor, Primary.
What interventions are being tested in trial NCT06185686?
The interventions under investigation include: Cognitive testing (OTHER), Resting State MRI/Precision functional mapping (DEVICE).
Who is sponsoring clinical trial NCT06185686?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06185686 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Brain Tumor, Primary
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02422641 · 16 participants · Phase 2
Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis
- NCT02851758 · 16 participants · NA
Transplantation of Autologously Derived Mitochondria Following Ischemia
- NCT03291028 · 16 participants
Analysis of Primary and Metastatic Tumors in Patients With Renal Cell Carcinoma and Urothelial Carcinoma
- NCT03425526 · 16 participants · Phase 1
Donor T Cell Therapy in Treating Immunocompromised Patients With Adenovirus-Related Disease
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI