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NCT06177106 · ClinicalTrials.gov registry record · NA
SUV PDL1/PD1 in Sun Damaged & Sun Protected Human Skin of Participants
A NA study of Other Skin Changes Due to Chronic Exposure to Nonionizing Radiation, sponsored by University of Arizona.
- Recruiting
- Registry status
- NA
- Development phase
- 46
- Enrollment target
- 1
- Study location
NCT06177106: Recruiting NA study of Other Skin Changes Due to Chronic Exposure to Nonionizing Radiation, sponsored by University of Arizona.
NCT06177106 is a NA study of Other Skin Changes Due to Chronic Exposure to Nonionizing Radiation that is actively recruiting participants, run by University of Arizona. The registered enrollment target is 46 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06177106, a NA study of Other Skin Changes Due to Chronic Exposure to Nonionizing Radiation, is actively recruiting participants, sponsored by University of Arizona.
- RECRUITING
- Registry status
- NA
- Development phase
- 46 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this research study is to look at how the proteins and genes in people's skin change when they're exposed to simulated sunlight. The researchers want to see if there are differences between people who've had skin cancer and those who haven't despite having a similar type of skin and history of sun exposure. Since this study is designed to simulate sun exposure to small areas of skin, mild to moderate sunburn and tanned spots at the site of the simulated sunlight exposure is a risk. In addition to simulated sun exposure, patients will also have four 6 mm punch skin biopsies performed. Brief discomfort may be felt when the local painkiller (lidocaine) is injected prior to skin biopsies; however, it is usually minimal. Participation in the study involves 4 visits to the clinic over the course of 4 weeks. Each visit will take no longer than 90 minutes.
Primary Outcome
The primary objective will be the relative increase in PD-L1 protein expression levels in the epidermal keratinocytes of subjects in two risk cohorts (Cohort A (history of \> 2 cSCC) and Cohort B (no history of cSCC)) after acute solar simulated light treatment compared to unexposed skin within the same subject. Proteomic evaluation will be performed by reverse phase protein microarray and confirmatory IHC (immunohistochemistry) stain.
Conditions Studied
Interventions
- OTHER Solar Simulated Light
Study Locations (1)
Arizona
- University of Arizona Cancer Center - Tucson
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 46 participants |
| Start Date | 2023-12-26 |
| Est. Completion | 2027-12-31 |
| Phase | NA |
What NCT06177106 shows while recruiting
NCT06177106 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 46 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Other Skin Changes Due to Chronic Exposure to Nonionizing Radiation appearing as the primary indexed condition, and to 1 intervention - of which Solar Simulated Light is the first listed.
NCT06177106 reports a single indexed study location in Arizona.
Frequently Asked Questions
What is clinical trial NCT06177106 about?
NCT06177106 is a clinical study titled "SUV PDL1/PD1 in Sun Damaged & Sun Protected Human Skin of Participants". The purpose of this research study is to look at how the proteins and genes in people's skin change when they're exposed to simulated sunlight. The researchers want to see if there are differences between people who've had skin cancer and those who haven't despite having a similar type of skin and h...
What is the current status of trial NCT06177106?
This trial is currently recruiting. It is a NA study. The enrollment target is 46 participants. The study started on 2023-12-26. Estimated completion is 2027-12-31.
What conditions does trial NCT06177106 study?
This clinical trial studies the following conditions: Other Skin Changes Due to Chronic Exposure to Nonionizing Radiation.
What interventions are being tested in trial NCT06177106?
The interventions under investigation include: Solar Simulated Light (OTHER).
Who is sponsoring clinical trial NCT06177106?
This trial is sponsored by University of Arizona, which has 349 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06177106 being conducted?
This trial has 1 study location across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06177106's enrollment target sits among peer trials
46 1403rd of 2000 higher than 590 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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