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NCT06170541 · ClinicalTrials.gov registry record · NA
CORE-COMPARE Pilot Study
A NA study of Coronary Heart Disease (CHD), sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- NA
- Development phase
- 140
- Enrollment target
- 1
- Study location
NCT06170541: Recruiting NA study of Coronary Heart Disease (CHD), sponsored by Johns Hopkins University.
NCT06170541 is a NA study of Coronary Heart Disease (CHD) that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 140 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06170541, a NA study of Coronary Heart Disease (CHD), is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- NA
- Development phase
- 140 participants
- Enrollment target
- 1
- Study location
Study Summary
The utility of Ultra High-Resolution Computed Tomography (UHR-CT) compared to conventional CT in all-comers (i.e., a generally lower-risk population) remains uncertain but is an important area of study in order to justify wider spread implementation and use of this technology, particularly in light of reports of significantly higher radiation exposure with UHR-CT, as well as longer scan times. The availability of technology to reconstruct conventional resolution (CR) simulation images from the raw CT acquisition data acquired on the UHR-CT scanner offers a unique platform to study this question without subjecting individuals to two different scans. The primary objective of this study is to generate preliminary data in support of the hypothesis that noninvasive UHR-CT is superior to conventional resolution CT for identifying patients with obstructive CHD.
Primary Outcome
The ultra-high-resolution CT images (UHRCT) and the reconstructed conventional CT resolution images (CRCT) will be independently reviewed by two observers (with a 60-day washout period between both images). The stenoses will be classified according to the Society of Cardiovascular Computed Tomography (SCCT) classification system (\<25%, 25-49%, 50-69%, 70-99%, and occluded). Patients with stenosis greater than 70% will be flagged. The primary outcome will be assessed for patients that underwent
Conditions Studied
Interventions
- DEVICE Aquilion Precision
- DEVICE Conventional Computed Tomography
Study Locations (1)
Maryland
- Johns Hopkins School of Medicine - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 140 participants |
| Start Date | 2021-04-05 |
| Est. Completion | 2027-04-05 |
| Phase | NA |
What NCT06170541 shows while recruiting
NCT06170541 is an interventional study that assigns participants to a tested intervention. The registered 140 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Coronary Heart Disease (CHD) appearing as the primary indexed condition, and to 2 interventions - of which Aquilion Precision is the first listed.
NCT06170541 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT06170541 about?
NCT06170541 is a clinical study titled "CORE-COMPARE Pilot Study". The utility of Ultra High-Resolution Computed Tomography (UHR-CT) compared to conventional CT in all-comers (i.e., a generally lower-risk population) remains uncertain but is an important area of study in order to justify wider spread implementation and use of this technology, particularly in light ...
What is the current status of trial NCT06170541?
This trial is currently recruiting. It is a NA study. The enrollment target is 140 participants. The study started on 2021-04-05. Estimated completion is 2027-04-05.
What conditions does trial NCT06170541 study?
This clinical trial studies the following conditions: Coronary Heart Disease (CHD).
What interventions are being tested in trial NCT06170541?
The interventions under investigation include: Aquilion Precision (DEVICE), Conventional Computed Tomography (DEVICE).
Who is sponsoring clinical trial NCT06170541?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06170541 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Coronary Heart Disease (CHD)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06170541's enrollment target sits among peer trials
140 713th of 2000 higher than 1,281 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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