Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06140823 · ClinicalTrials.gov registry record
Prospective Validation of Liver Cancer Risk Computation (LIRIC) Models
A clinical trial of Predictive Cancer Model, sponsored by Beth Israel Deaconess Medical Center.
- Active
- Registry status
- 6,000,000
- Enrollment target
- 1
- Study location
NCT06140823: Active study of Predictive Cancer Model, sponsored by Beth Israel Deaconess Medical Center.
NCT06140823 is a study of Predictive Cancer Model that is active but no longer recruiting, run by Beth Israel Deaconess Medical Center. The registered enrollment target is 6,000,000 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06140823, a study of Predictive Cancer Model, is active but no longer recruiting, sponsored by Beth Israel Deaconess Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- 6,000,000 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this prospective observational cohort study is to validate previously developed Hepatocellular Carcinoma (HCC) risk prediction algorithms, the Liver Risk Computation (LIRIC) models, which are based on electronic health records. The main questions it aims to answer are: * Will our retrospectively developed general population LIRIC models, developed on routine EHR data, perform similarly when prospectively validated, and reliably and accurately predict HCC in real-time? * What is the average time from model deployment and risk prediction, to the date of HCC development and what is the stage of HCC at diagnosis? The risk model will be deployed on data from individuals eligible for the study. Each individual will be assigned a risk score and tracked over time to assess the model's discriminatory performance and calibration.
Primary Outcome
To assess the discriminatory performance of LIRIC for prospective identification of high-risk individuals for HCC development. ROCs and AUROC numbers will be calculated for the whole population and groups stratified by age, sex, race, and geographical location.
Conditions Studied
Interventions
- OTHER Liver Risk Computation Model (LIRIC)
- OTHER Liver Risk Computation Model (LIRIC)_cirrhosis
- OTHER Liver Risk Computation Model (LIRIC)_no_cirrhosis
Study Locations (1)
Massachusetts
- Beth Israel Deaconess Medical Center - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6,000,000 participants |
| Start Date | 2023-04-01 |
| Est. Completion | 2027-03-31 |
What the registry record for NCT06140823 still lists
NCT06140823 is an observational study that tracks outcomes without assigning an intervention. Its 6,000,000 participants enrollment target places it among the larger protocols in the corpus.
The record links to 1 condition, with Predictive Cancer Model appearing as the primary indexed condition, and to 3 interventions - of which Liver Risk Computation Model (LIRIC) is the first listed.
NCT06140823 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06140823 about?
NCT06140823 is a clinical study titled "Prospective Validation of Liver Cancer Risk Computation (LIRIC) Models". The goal of this prospective observational cohort study is to validate previously developed Hepatocellular Carcinoma (HCC) risk prediction algorithms, the Liver Risk Computation (LIRIC) models, which are based on electronic health records. The main questions it aims to answer are: * Will our retro...
What is the current status of trial NCT06140823?
This trial is currently active not recruiting. The enrollment target is 6,000,000 participants. The study started on 2023-04-01. Estimated completion is 2027-03-31.
What conditions does trial NCT06140823 study?
This clinical trial studies the following conditions: Predictive Cancer Model.
What interventions are being tested in trial NCT06140823?
The interventions under investigation include: Liver Risk Computation Model (LIRIC) (OTHER), Liver Risk Computation Model (LIRIC)_cirrhosis (OTHER), Liver Risk Computation Model (LIRIC)_no_cirrhosis (OTHER).
Who is sponsoring clinical trial NCT06140823?
This trial is sponsored by Beth Israel Deaconess Medical Center, which has 488 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06140823 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Predictive Cancer Model
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02693223 · 3,892,063 participants
Get With the Guidelines-Stroke Registry
- NCT06803498 · 3,000,000 participants
Delivery Room Intervention and Evaluation Network
- NCT05678699 · 10,000,000 participants · NA
The Effects of Medicaid Policy Interventions on Racial Equity in Severe Maternal Morbidity
- NCT03813862 · 2,000,000 participants
Observational Pharmaco-Epidemiology Research & Analysis
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI