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ACTIVE NOT RECRUITING

Prospective Validation of Liver Cancer Risk Computation (LIRIC) Models

NCT06140823 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this prospective observational cohort study is to validate previously developed Hepatocellular Carcinoma (HCC) risk prediction algorithms, the Liver Risk Computation (LIRIC) models, which are based on electronic health records. The main questions it aims to answer are: * Will our retrospectively developed general population LIRIC models, developed on routine EHR data, perform similarly when prospectively validated, and reliably and accurately predict HCC in real-time? * What is the average time from model deployment and risk prediction, to the date of HCC development and what is the stage of HCC at diagnosis? The risk model will be deployed on data from individuals eligible for the study. Each individual will be assigned a risk score and tracked over time to assess the model's discriminatory performance and calibration.

Conditions Studied

Interventions

  • OTHER Liver Risk Computation Model (LIRIC)
  • OTHER Liver Risk Computation Model (LIRIC)_cirrhosis
  • OTHER Liver Risk Computation Model (LIRIC)_no_cirrhosis

Study Locations (1)

Massachusetts

  • Beth Israel Deaconess Medical Center — Boston

Trial Details

FieldValue
Enrollment Target 6,000,000 participants
Start Date 2023-04-01
Est. Completion 2027-03-31

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06140823

The ClinicalTrials.gov registry entry for NCT06140823 describes a study currently listed as active not recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 6,000,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Beth Israel Deaconess Medical Center, which has 434 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Predictive Cancer Model appearing as the primary indexed condition, and to 3 interventions — of which Liver Risk Computation Model (LIRIC) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06140823 reports 1 study location spanning 1 distinct geographic area — top geographies include Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06140823 about?

NCT06140823 is a clinical study titled "Prospective Validation of Liver Cancer Risk Computation (LIRIC) Models". The goal of this prospective observational cohort study is to validate previously developed Hepatocellular Carcinoma (HCC) risk prediction algorithms, the Liver Risk Computation (LIRIC) models, which are based on electronic health records. The main questions it aims to answer are: * Will our retro...

What is the current status of trial NCT06140823?

This trial is currently active not recruiting. The enrollment target is 6,000,000 participants. The study started on 2023-04-01. Estimated completion is 2027-03-31.

What conditions does trial NCT06140823 study?

This clinical trial studies the following conditions: Predictive Cancer Model. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06140823?

The interventions under investigation include: Liver Risk Computation Model (LIRIC) (OTHER), Liver Risk Computation Model (LIRIC)_cirrhosis (OTHER), Liver Risk Computation Model (LIRIC)_no_cirrhosis (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06140823?

This trial is sponsored by Beth Israel Deaconess Medical Center, which has 434 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06140823 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial