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NCT06139107 · ClinicalTrials.gov registry record · Phase 1

RADIANT: Pre-op Radiation With Abemaciclib and Letrozole

A Phase 1 study of Breast Cancer, sponsored by Mridula George, MD.

Recruiting
Registry status
Phase 1
Development phase
15
Enrollment target
4
Study locations

NCT06139107 is a Phase 1 study of Breast Cancer that is actively recruiting participants, run by Mridula George, MD. The registered enrollment target is 15 participants, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (99% lower). The trial reports 4 study locations across 1 state.

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The verdict

NCT06139107, a Phase 1 study of Breast Cancer, is actively recruiting participants, sponsored by Mridula George, MD.

RECRUITING
Registry status
Phase 1
Development phase
15 participants
Enrollment target
4
Study locations

Study Summary

This phase 1b study investigates the safety and feasibility of combining pre-operative radiation therapy with Cyclin-Dependent Kinase 4 (CDK4/6) inhibitors in participants with hormone receptor positive/HER2 negative (HR+/HER2-) breast cancer. The study aims to assess the benefits of concurrent use of these treatments in a specific participant population, focusing on their safety and tolerability. The hypothesis is that the combination therapy will be well-tolerated, providing valuable insights into its effectiveness for future clinical applications.

Conditions Studied

Breast Cancer

Interventions

  • DRUG Letrozole
  • DRUG Abemaciclib

Study Locations (4)

New Jersey

  • RWJBarnabas Health Clara Maas Medical Center - Belleville
  • Cooperman Barnabas Medical Center - Livingston
  • Rutgers Cancer Institute of New Jersey - New Brunswick
  • RWJBarnabas Health - Robert Wood Johnson University Hospital Somerset - Somerville

Trial Details

FieldValue
Enrollment Target 15 participants
Start Date 2024-08-22
Est. Completion 2032-09-30
Phase Phase 1

Sponsor

Mridula George, MD

3 total trials

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What the Registry Record Tells You About NCT06139107

The ClinicalTrials.gov registry entry for NCT06139107 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (99% lower). The listed sponsor is Mridula George, MD, which has 3 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions - of which Letrozole is the first listed.

NCT06139107 reports 4 study locations spanning 1 distinct geographic area - top geographies include New Jersey.

Frequently Asked Questions

What is clinical trial NCT06139107 about?

NCT06139107 is a clinical study titled "RADIANT: Pre-op Radiation With Abemaciclib and Letrozole". This phase 1b study investigates the safety and feasibility of combining pre-operative radiation therapy with Cyclin-Dependent Kinase 4 (CDK4/6) inhibitors in participants with hormone receptor positive/HER2 negative (HR+/HER2-) breast cancer. The study aims to assess the benefits of concurrent use ...

What is the current status of trial NCT06139107?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 15 participants. The study started on 2024-08-22. Estimated completion is 2032-09-30.

What conditions does trial NCT06139107 study?

This clinical trial studies the following conditions: Breast Cancer.

What interventions are being tested in trial NCT06139107?

The interventions under investigation include: Letrozole (DRUG), Abemaciclib (DRUG).

Who is sponsoring clinical trial NCT06139107?

This trial is sponsored by Mridula George, MD, which has 3 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06139107 being conducted?

This trial has 4 study locations across New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.