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NCT06105541 · ClinicalTrials.gov registry record · NA
Hypermobile Ehlers-Danlos Syndrome - Transcutaneous Auricular Neuromodulation
A NA study, sponsored by Medical University of South Carolina.
- Completed
- Registry status
- NA
- Development phase
- 25
- Enrollment target
NCT06105541: Completed NA study, sponsored by Medical University of South Carolina.
NCT06105541 is a NA study that has completed, run by Medical University of South Carolina. The registered enrollment target is 25 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06105541, a NA study, has completed, sponsored by Medical University of South Carolina.
- COMPLETED
- Registry status
- NA
- Development phase
- 25 participants
- Enrollment target
Study Summary
Investigate whether at-home transcutaneous auricular VNS (tAN: transcutaneous auricular neurostimulation) improves a battery of nine key physical and psychological symptoms of a group of hEDS (Hypermobile Ehlers-Danlos Syndrome \& Hypermobile Spectrum Disorder) patients (n=30) using a randomized, double blind, sham controlled design. The study team will collect clinical measures at baseline, after a two-week double-blind intervention phase, after a following two-week open-label phase and finally at three months post intervention. The study team will test patients in the following domains: pain, fatigue, sleep, anxiety, depression, quality of life, GI function, immune function and autonomic function.
Primary Outcome
The investigators have created an Ehlers-Danlos Syndrome Symptom Battery that measures a variety of different primary and secondary symptoms associated with Ehlers-Danlos Syndrome, including: Pain, Fatigue, Sleep, Anxiety, Depression, Quality of Life, and Gastrointestinal issues
Interventions
- DEVICE Transcutaneous Auricular Neurostimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2023-07-05 |
| Est. Completion | 2026-02-04 |
| Phase | NA |
What the finished NCT06105541 record still lists
NCT06105541 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 1 intervention - of which Transcutaneous Auricular Neurostimulation is the first listed.
NCT06105541 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06105541 about?
NCT06105541 is a clinical study titled "Hypermobile Ehlers-Danlos Syndrome - Transcutaneous Auricular Neuromodulation". Investigate whether at-home transcutaneous auricular VNS (tAN: transcutaneous auricular neurostimulation) improves a battery of nine key physical and psychological symptoms of a group of hEDS (Hypermobile Ehlers-Danlos Syndrome \& Hypermobile Spectrum Disorder) patients (n=30) using a randomized, do...
What is the current status of trial NCT06105541?
This trial is currently completed. It is a NA study. The enrollment target is 25 participants. The study started on 2023-07-05. Estimated completion is 2026-02-04.
What interventions are being tested in trial NCT06105541?
The interventions under investigation include: Transcutaneous Auricular Neurostimulation (DEVICE).
Who is sponsoring clinical trial NCT06105541?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06105541's enrollment target sits among peer trials
25 1712th of 2000 higher than 265 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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